Evidence map›Paper›PMID 29764853›Full record

Trial reportClinical cancer research : an official journal of the American Association for Cancer Research2018

Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors.

Daniel D Von Hoff, Drew W Rasco, Elisabeth I Heath, Pamela N Munster, Jan H M Schellens, Nicolas Isambert, Christophe Le Tourneau, Bert O'Neil, Ron H J Mathijssen, Jose A Lopez-Martin and 9 more

Open access · bronzeAbstract readClinical Trial, Phase IMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Article
  5. Review
  6. Epigenetics-targeted drugs: current paradigms and future challenges.Signal transduction and targeted therapy · 2024
    Review
  7. Article
  8. Review
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  11. Review
  12. Article
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  19. Article
  20. Key actors in cancer therapy: epigenetic modifiers.Turkish journal of biology = Turk biyoloji dergisi · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 14 institutions in 5 countries.

Daniel D Von HoffTranslational Genomics Research Institute, Phoenix, Arizona.
Drew W RascoSouth Texas Accelerated Research Therapeutics, San Antonio, Texas.
Elisabeth I HeathKarmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Pamela N MunsterDepartment of Medicine, University of California, San Francisco, California.
Jan H M SchellensThe Netherlands Cancer Institute, Antoni Van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Nicolas IsambertCentre Georges Francois Leclerc, Dijon, France.
Christophe Le TourneauDepartment of Medical Oncology, Institut Curie, Paris & Saint-Cloud, France.
Bert O'NeilIndiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana.
Ron H J MathijssenErasmus MC Cancer Institute, Rotterdam, the Netherlands.
Jose A Lopez-Martin12 de Octubre University Hospital & Research Institute, Madrid, Spain.ORCID 0000-0001-7530-3207
W Jeff EdenfieldGreenville Memorial Hospital, University of South Carolina, Greenville, South Carolina.
Miguel MartinHospital General Universitario Gregorio Maranon, Madrid, Spain.ORCID 0000-0001-9237-3231
Patricia M LoRussoKarmanos Cancer Institute, Detroit, Michigan.
Gordon L BrayCelgene Corporation, Summit, New Jersey.
Jorge DiMartinoCelgene Corporation, Summit, New Jersey.
Aaron NguyenCelgene Corporation, Summit, New Jersey.
Kejian LiuCelgene Corporation, Summit, New Jersey.
Eric LailleCelgene Corporation, Summit, New Jersey.
Johanna C BendellSarah Cannon Research Institute/Tennessee Oncology, Nashville, Tennessee. jbendell@tnonc.com.
Bristol-Myers Squibb (Switzerland) · CHThe Barbara Ann Karmanos Cancer Institute · USCentre Georges François Leclerc · FRErasmus MC Cancer Institute · NLGreenville Memorial Hospital · USIndiana University Health · USInserm · FRNetherlands Cancer Institute-Antoni van Leeuwenhoek Hospital · NLResearch Institute Hospital 12 de Octubre · ESSouth Texas Accelerated Research Therapeutics · USTennessee Oncology · USTranslational Genomics Research Institute · USUniversidad Complutense de Madrid · ESUniversity of California, San Francisco · US

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
NCI NIH HHS P30 CA022453
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAlbuminsAntineoplastic Combined Chemotherapy ProtocolsAzacitidineCarboplatinDisease-Free SurvivalDrug Administration ScheduleFemaleHumansMaleMaximum Tolerated DoseMiddle AgedNeoplasmsPaclitaxelTreatment Outcome130-nm albumin-bound paclitaxelAlbuminsAzacitidineCarboplatinPaclitaxel

Identifiers

PMID29764853
PMCPMC6853187
OpenAlexW2803889088

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.