Evidence map›Paper›PMID 29764451›Full record

ArticleMalaria journal2018

Phenotypic and genotypic characterization of Thai isolates of Plasmodium falciparum after an artemisinin resistance containment project.

Thunyapit Thita, Pimrat Jadsri, Jarupatr Thamkhantho, Toon Ruang-Areerate, Nantana Suwandittakul, Naruemon Sitthichot, Kittiya Mahotorn, Peerapan Tan-Ariya, Mathirut Mungthin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Thunyapit ThitaDepartment of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Pimrat JadsriDepartment of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Jarupatr ThamkhanthoDepartment of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Toon Ruang-AreerateDepartment of Parasitology, Phramongkutklao College of Medicine, Bangkok, Thailand.
Nantana SuwandittakulDepartment of Parasitology, Phramongkutklao College of Medicine, Bangkok, Thailand.
Naruemon SitthichotDepartment of Parasitology, Phramongkutklao College of Medicine, Bangkok, Thailand.
Kittiya MahotornDepartment of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Peerapan Tan-AriyaDepartment of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Mathirut MungthinDepartment of Parasitology, Phramongkutklao College of Medicine, Bangkok, Thailand. mathirut@hotmail.com.
Mahidol University · THPhramongkutklao College of MedicinePhramongkutklao Hospital · TH

Funding

the Health System Research Institute P-13-50112
6 · The paper itself

Abstract

backgroundIn Thailand, artemisinin-based combination therapy (ACT) has been used to treat uncomplicated falciparum malaria since 1995. Unfortunately, artemisinin resistance has been reported from Thailand and other Southeast Asian countries since 2003. Malarone

resultsOne hundred and nine of P. falciparum isolates collected from Thai-Cambodia border from Chanthaburi and Trat provinces during 1988-2016 were used in this study. Of these, 58 isolates were collected after the containment. These parasite isolates were characterized for in vitro antimalarial sensitivities including chloroquine (CQ), quinine (QN), mefloquine (MQ), piperaquine (PPQ), artesunate (AS), dihydroartemisinin (DHA), ATQ and PG and genetic markers for drug resistance including the Kelch13 (k13), Plasmodium falciparum chloroquine resistance transporter (pfcrt), P. falciparum multidrug resistance 1 (pfmdr1) and cytochrome b (cytb) genes. Mean CQ, QN, MQ, PPQ and AS IC

conclusionsAlthough the containment project had been implemented in this area, the expansion of artemisinin-resistant parasites did not decline. In addition, reduced sensitivity of the partner drugs of ACT including MQ and PPQ were identified.

Indexed as

AntimalarialsArtemisininsDrug ResistanceGenotypePhenotypePlasmodium falciparumThailandAntimalarialsartemisininArtemisininsArtemisin-based combination therapyArtemisinin resistance containment projectDrug resistanceGenetic markersIn vitro sensitivityPlasmodium falciparumThai-Cambodian

Identifiers

PMID29764451
PMCPMC5952644
OpenAlexW2805257471

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.