ArticleBMC cancer2018
Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala.
Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Efficient high-risk human papillomavirus screening through pooled testing: a simulation study based on real-world data in low- and middle-income countries.Journal of global health · 2026Article
- Development of a Cervical Cancer Screening Program in Rural Guatemala.Global health, science and practice · 2025Article
- HPV and Cervical Cancer: Molecular and Immunological Aspects, Epidemiology and Effect of Vaccination in Latin American Women.Viruses · 2024Review
- High-risk HPV prevalence and genotype distribution among women in Liaocheng, Shandong Province, China from 2016 to 2022.Frontiers in public health · 2023Article
- Screen, Notify, See, and Treat: Initial Results of Cervical Cancer Screening and Treatment in Rwanda.JCO global oncology · 2021Article
- HPV Prevalence and Genotype Distribution Among Women From Hengyang District of Hunan Province, China.Frontiers in public health · 2021Article
- Correction to: Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala.BMC cancer · 2020Article
- HPV self-sampling acceptability in rural and indigenous communities in Guatemala: a cross-sectional study.BMJ open · 2019Article
- Barriers to Cervical Cancer Screening and the Cervical Cancer Care Continuum in Rural Guatemala: A Mixed-Method Analysis.Journal of global oncology · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
24 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundA low cost and accurate method for detecting high-risk (HR) human papillomavirus (HPV) is important to permit HPV testing for cervical cancer prevention. We used a commercially available HPV method (H13, Hybribio) which was documented to function accurately in a reduced volume of cervical specimen to determine the most prevalent HPV types and the distribution of HPV infections in over 1795 cancer-free women in Guatemala undergoing primary screening for cervical cancer by cytology.
methodsHR-HPV detection was attempted in cervical samples from 1795 cancer-free women receiving Pap smears using the Hybribio™ real-time PCR assay of 13 HR types. The test includes a globin gene internal control. HPV positive samples were sequenced to determine viral type. Age-specific prevalence of HPV was also assessed in the study population.
resultsA total of 13% (226/1717) of women tested HPV+, with 78 samples (4.3%) failing to amplify the internal control. The highest prevalence was found in younger women (< 30 years, 22%) and older ones (≥60 years, 15%). The six most common HR-HPV types among the 148 HPV+ typed were HPV16 (22%), HPV18 (11%), HPV39 (11%), HPV58 (10%), HPV52 (8%), and HPV45 (8%).
conclusionsIn this sample of cancer free women in Guatemala, HPV16 was the most prevalent HR type in Guatemala and the age-specific prevalence curve peaked in younger ages. Women in the 30-59-year age groups had a prevalence of HR-HPV of 8%, however, larger studies to better describe the epidemiology of HPV in Guatemala are needed.
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