ArticleBMC geriatrics2018
Osteoporosis, diabetes, and hypertension are major risk factors for mortality in older adults: an intermediate report on a prospective survey of 1467 community-dwelling elderly healthy pensioners in Switzerland.
Article in BMC geriatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Pooled it
- Prevalence of malnutrition among old people in Africa: systematic review and meta-analysis.BMJ open · 2022Pooled it
- The relationship between geriatric nutritional risk index and cardiovascular disease and all-cause mortality in patients with osteoporosis and osteopenia.Journal of geriatric cardiology : JGC · 2025Article
- Polyphenolic Composition, Antioxidant Activity, and Cytotoxic Effect of Male Floral Buds from ThreeMolecules (Basel, Switzerland) · 2025Article
- Effectiveness of Spironolactone in Reducing Osteoporosis and Future Fracture Risk in Middle-Aged and Elderly Hypertensive Patients.Drug design, development and therapy · 2024Article
- Correlation between plasma aldosterone concentration and bone mineral density in middle-aged and elderly hypertensive patients: potential impact on osteoporosis and future fracture risk.Frontiers in endocrinology · 2024Article
- Drynaria Naringin alleviated mechanical stress deficiency-caused bone loss deterioration via Rspo1/Lgr4-mediated Wnt/β-catenin signalling pathway.In vitro cellular & developmental biology. Animal · 2023Article
- Mortality risk factors in community-dwelling, subjectively healthy, Swiss older adults: update after 8-years follow-up.BMC geriatrics · 2023Article
- Health-promoting behavior to enhance perceived meaning and control of life in chronic disease patients with role limitations and depressive symptoms: a network approach.Scientific reports · 2023Article
- Analysis of the prevalence, risk factors, and clinical characteristics of osteoporosis in patients with essential hypertension.BMC endocrine disorders · 2022Article
- Prevalence of malnutrition among old age people in Africa.Frontiers in aging · 2022Review
- Causal Effects of Genetically Predicted Cystatin C on Osteoporosis: A Two-Sample Mendelian Randomization Study.Frontiers in genetics · 2022Article
- Association of vitamin D receptor gene polymorphism with the occurrence of low bone density, osteopenia, and osteoporosis in patients with type 2 diabetes.Journal of diabetes and metabolic disorders · 2021Article
- Article
- Modifiable risk factors for 9-year mortality in older English and Brazilian adults: The ELSA and SIGa-Bagé ageing cohorts.Scientific reports · 2020Article
- A novel quantitative method for estimating bone mineral density using B-mode ultrasound and radiofrequency signals-a pilot study on patients with rheumatoid arthritis.Experimental and therapeutic medicine · 2019Article
- The importance of updating osteoporotic femur fracture data: Asian Federation of Osteoporosis Societies study.Osteoporosis and sarcopenia · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoporosis is an important morbidity factor for ageing populations in developed countries. However, compared to the amount of information available on diabetes and cardiovascular disease, little is known about the direct impact of osteoporosis on general mortality in older age.
methodsWe obtained data from a prospective population-based cohort of pensioners from the SENIORLAB study who were subjectively healthy. The inclusion criteria were an age of at least 60 years and Swiss residence. We assessed and analysed clinical measures, voluntary reports, and laboratory values.
resultsIn total, 1467 subjects were included in the cohort. The mean follow-up time was 3.68 years (95% confidence interval, 3.64-3.71). The ages of the included participants ranged from 60 to 99 years. At follow-up, there were 1401 survivors, and 66 participants had died. According to the multivariate analysis (Cox regression), osteoporosis was the most important risk factor for all-cause mortality (hazard ratio, 4.46; 95% confidence interval, 1.82-10.91), followed by diabetes (hazard ratio, 2.17; 95% confidence interval, 1.04-4.52) and hypertension (hazard ratio, 1.81; 95% confidence interval, 1.09-3.03).
conclusionsOsteoporosis is a major risk factor for all-cause mortality in a subjectively healthy senior population, followed by type 2 diabetes mellitus and hypertension. Osteoporosis should be more actively diagnosed in healthy pensioners before they develop osteoporosis-associated health incidents.
trial registrationThe present study was registered in the International Standard Randomized Controlled Trial Number registry: ISRCTN53778569 .
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