ArticlePharmacoepidemiology and drug safety2018
Development of an algorithm to identify pregnancy episodes and related outcomes in health care claims databases: An application to antiepileptic drug use in 4.9 million pregnant women in France.
Article in Pharmacoepidemiology and drug safety, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 68 citations in OpenAlex.
- Assessing the Risk of Adverse Maternal and Infant Outcomes Following Prenatal Modafinil Exposure: A French Nationwide Cohort Study.Drug safety · 2026Article
- Developing a Hierarchical Algorithm to Identify Pregnancies and Determine Gestational Age from Nationwide Linked Health Data in Taiwan.Drug safety · 2026Article
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- Prenatal Exposure to Modafinil and the Risk of Major Congenital Anomalies and Other Adverse Neonatal and Pediatric Outcomes.Pharmacoepidemiology and drug safety · 2026Article
- Identifying Pregnancies in Population-Based Data Sources: Development and Application of the ConcePTION Pregnancy Algorithm.Pharmacoepidemiology and drug safety · 2026Article
- Readmission and Late Mortality Among Children With Congenital Diaphragmatic Hernia.JAMA network open · 2026Article
- Identifying pregnancies in routinely collected health data: a scoping review of methods.BMC medical informatics and decision making · 2026Article
- Ultrasound Procedure Codes Enable Timely Surveillance of Ongoing Pregnancies: A Nationwide Population-Based Register Study.Pharmacoepidemiology and drug safety · 2026Article
- Appropriate definition of childbirth using Japanese administrative database: a cross-sectional cohort validation study.BMC pregnancy and childbirth · 2026Article
- Therapeutic Strategies After Discontinuation of Valproate By Females with Epilepsy of Child-Bearing Potential: An Insurance Claims Database Study in France and the United Kingdom.Clinical drug investigation · 2026Article
- Methods to establish a Pregnancy Register in the QResearch Database.Communications medicine · 2025Article
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- Relative Age in School and Initiation of Speech Therapy in Children.JAMA network open · 2025Article
- First-trimester exposure to macrolides and risk of major congenital malformations compared with amoxicillin: A French nationwide cohort study.PLoS medicine · 2025Article
- Maternal and neonatal outcomes of pregnancies after metabolic bariatric surgery: a retrospective population-based study.The Lancet regional health. Europe · 2025Article
- Assessing the Risk of Relapse After In Vitro Fertilization in Women With Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Prenatal Exposure to Proton Pump Inhibitors and Risk of Serious Infections in Offspring During the First Year of Life: A Nationwide Cohort Study.Drug safety · 2025Article
- High-Dose Cyproterone Acetate and Intracranial Meningioma: Impact of the Risk Minimisation Measures Implemented in France in 2018-2019.Pharmacoepidemiology and drug safety · 2025Article
- In Utero Exposure to Antibiotics and Risk of Serious Infections in the First Year of Life.Drug safety · 2024Article
- Use of multiple sclerosis disease-modifying therapies during pregnancy in France: Nationwide study between 2010 and 2021.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAccess to claims databases provides an opportunity to study medication use and safety during pregnancy. We developed an algorithm to identify pregnancy episodes in the French health care databases and applied it to study antiepileptic drug (AED) use during pregnancy between 2007 and 2014.
methodsThe algorithm searched the French health care databases for discharge diagnoses and medical procedures indicative of completion of a pregnancy. To differentiate claims associated with separate pregnancies, an interval of at least 28 weeks was required between 2 consecutive pregnancies resulting in a birth and 6 weeks for terminations of pregnancy. Pregnancy outcomes were categorized into live births, stillbirths, elective abortions, therapeutic abortions, spontaneous abortions, and ectopic pregnancies. Outcome dates and gestational ages were used to calculate pregnancy start dates.
resultsAccording to our algorithm, live birth was the most common pregnancy outcome (73.9%), followed by elective abortion (17.2%), spontaneous abortion (4.2%), ectopic pregnancy (1.1%), therapeutic abortion (1.0%), and stillbirth (0.4%). These results were globally consistent with French official data. Among 7 559 701 pregnancies starting between 2007 and 2014, corresponding to 4 900 139 women, 6.7 per 1000 pregnancies were exposed to an AED. The number of pregnancies exposed to older AEDs, comprising the most teratogenic AEDs, decreased throughout the study period (-69.4%), while the use of newer AEDs increased (+73.4%).
conclusionsWe have developed an algorithm that allows identification of a large number of pregnancies and all types of pregnancy outcomes. Pregnancy outcome and start dates were accurately identified, and maternal data could be linked to neonatal data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.