Evidence map›Paper›PMID 29763835›Full record

ArticleAddictive behaviors2018

Predictors of reduced smoking quantity among recovering alcohol dependent men in a smoking cessation trial.

Matthew J Worley, Melodie Isgro, Jaimee L Heffner, Soo Yong Lee, Belinda E Daniel, Robert M Anthenelli

Abstract read
In one paragraph

Article in Addictive behaviors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matthew J WorleyPacific Treatment and Research Center (Pac-TARC), 3350 La Jolla Village Drive, 116A, San Diego, CA 92161, United States; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0821, United States. Electronic address: mworley@ucsd.edu.
Melodie IsgroPacific Treatment and Research Center (Pac-TARC), 3350 La Jolla Village Drive, 116A, San Diego, CA 92161, United States; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0821, United States.
Jaimee L HeffnerFred Hutchinson Cancer Research Center, 1100 Fairview Ave N., M3-B232, PO Box 19024, Seattle, WA 98109, United States.
Soo Yong LeeDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0821, United States.
Belinda E DanielPacific Treatment and Research Center (Pac-TARC), 3350 La Jolla Village Drive, 116A, San Diego, CA 92161, United States.
Robert M AnthenelliPacific Treatment and Research Center (Pac-TARC), 3350 La Jolla Village Drive, 116A, San Diego, CA 92161, United States; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0821, United States.

Funding

INIA: Stress, Anxiety of Alcohol AbuseU01AA013641 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GRANT, KATHLEEN A · 2002 to 2015
$8.8M
New Pharmacotherapy for Alcohol and Co-morbid DisordersR01AA019720 · NIAAA · UNIVERSITY OF VIRGINIA · PI AIT-DAOUD, NASSIMA, ANTHENELLI, ROBERT M · 2010 to 2014
$4.4M
Behavioral economic mechanisms of prescription opioid addiction in chronic painK23DA039348 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WORLEY, MATTHEW J. · 2016 to 2020
$1.0M
NIAAA NIH HHS R01 AA019720NIAAA NIH HHS U01 AA013641NIDA NIH HHS K23 DA039348
6 · The paper itself

Abstract

introductionAdults with alcohol dependence (AD) have exceptionally high smoking rates and poor smoking cessation outcomes. Discovery of factors that predict reduced smoking among AD smokers may help improve treatment. This study examined baseline predictors of smoking quantity among AD smokers in a pharmacotherapy trial for smoking cessation.

methodsThe sample includes male, AD smokers (N = 129) with 1-32 months of alcohol abstinence who participated in a 12-week trial of medication (topiramate vs. placebo) and adjunct counseling with 6 months of follow-up. Baseline measures of nicotine dependence, AD severity, psychopathology, motivation to quit smoking, and smoking-related cognitions were used to predict smoking quantity (cigarettes per day) at post-treatment and follow-up.

resultsOverall, the sample had statistically significant reductions in smoking quantity. Greater nicotine dependence (Incidence rate ratios (IRRs) = 0.82-0.90), motivation to quit (IRRs = 0.65-0.85), and intrinsic reasons for quitting (IRRs = 0.96-0.98) predicted fewer cigarettes/day. Conversely, greater lifetime AD severity (IRR = 1.02), depression severity (IRRs = 1.05-1.07), impulsivity (IRRs = 1.01-1.03), weight-control expectancies (IRRs = 1.10-1.15), and childhood sexual abuse (IRRs = 1.03-1.07) predicted more cigarettes/day.

conclusionsSmokers with AD can achieve large reductions in smoking quantity during treatment, and factors that predict smoking outcomes in the general population also predict greater smoking reductions in AD smokers. Treatment providers can use severity of nicotine dependence and AD, motivation to quit, smoking-related cognitions, and severity of depression to guide treatment and improve outcomes among AD smokers.

Indexed as

Smoking ReductionAdultAdult Survivors of Child AbuseAlcohol AbstinenceAlcoholismCognitionDepressionHumansImpulsive BehaviorMaleMiddle AgedMotivationPrognosisRandomized Controlled Trials as TopicSmokingSmoking CessationTopiramateAlcohol dependenceNicotineSmoking cessationTobacco

Identifiers

PMID29763835
PMCPMC6357959

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.