Evidence map›Paper›PMID 29763732›Full record

ReviewBiochimica et biophysica acta. Molecular and cell biology of lipids2019

Development, activation, and therapeutic potential of thermogenic adipocytes.

Margo P Emont, Dong-Il Kim, Jun Wu

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Hederagenin fromPlants (Basel, Switzerland) · 2024
    Article
  6. Betanin from Beetroot (Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Margo P EmontLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Dong-Il KimLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Jun WuLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: wujunz@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
The role of immune-adipocyte cholinergic signaling during metabolic adaptation and dysfunctionR01DK107583 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WU, JUN · 2016 to 2024
$3.4M
Regulation of Thermogenesis in Adipocytes Through TRPA1F31DK112625 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EMONT, MARGO PREMINGER · 2016 to 2017
$48k
NIDDK NIH HHS F31 DK112625NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK107583
6 · The paper itself

Abstract

During the last decade, significant progress has been made in understanding adipocytes with a particular focus on thermogenic fat cells, which effectively convert chemical energy into heat in addition to their other metabolic functions. It has been increasingly recognized that different types and subtypes of adipocytes exist and the developmental origins of various types of fat cells are being intensively investigated. Previous work using immortalized fat cell lines has established an intricate transcriptional network that regulates adipocyte function. Recent work has illustrated how these key transcriptional components mediate thermogenic activation in fat cells. Last but not least, cumulative evidence supports an incontestable role of thermogenic fat in influencing systemic metabolism in humans. Here we summarize the exciting advancements in our understanding of thermogenic fat, discuss the advantages and limitations of the experimental tools currently available, and explore the future directions of this fast-evolving field.

Indexed as

ThermogenesisAdipocytesAdipose TissueAnimalsHumansTranscription, GeneticBeige fatBrown fatHuman fatObesityThermogenesis

Identifiers

PMID29763732
PMCPMC6240366
OpenAlexW2804228356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.