Evidence map›Paper›PMID 29763657›Full record

Trial reportContemporary clinical trials2018

A mHealth-based care model for improving hypertension control in stroke survivors: Pilot RCT.

Kamakshi Lakshminarayan, Sarah Westberg, Carin Northuis, Candace C Fuller, Farah Ikramuddin, Mustapha Ezzeddine, Julie Scherber, Stuart Speedie

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Contemporary clinical trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01875094 phase1 / phase2completednot on this map

Promoting Self-Management in Stroke Survivors Using Health IT

TypeinterventionalSponsorUniversity of MinnesotaRan2012 to 2016Enrolled56ConditionsStroke, HypertensionArmsSelf-Management / MTM using Health IT
NCT04010344 nacompletednot on this mapstarted 2019, after this paper: background citation

Addressing Hypertension Control in Africa (ADHINCRA) Study

TypeinterventionalSponsorJohns Hopkins UniversityRan2019 to 2024Enrolled240ConditionsHypertension, Diabetes, TelemedicineArmsEnhanced Usual Care Group, Usual Care Group
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  2. Impact of patient care teams on blood pressure control in patients with hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kamakshi LakshminarayanDivision of Epidemiology & Community Health, University of Minnesota, School of Public Health, United States. Electronic address: laksh004@umn.edu.
Sarah WestbergDepartment of Pharmaceutical Care and Health Systems, University of Minnesota, College of Pharmacy, United States.
Carin NorthuisDivision of Epidemiology & Community Health, University of Minnesota, School of Public Health, United States.
Candace C FullerDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, United States.
Farah IkramuddinDepartment of Rehabilitation Medicine, University of Minnesota, United States.
Mustapha EzzeddineDepartment of Neurology, University of Minnesota, United States.
Julie ScherberDepartment of Medicine, University of Minnesota, United States.
Stuart SpeedieInstitute for Health Informatics, University of Minnesota, United States.

Funding

Cardiovascular Disease Epidemiology &Prevention TrngT32HL007779 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PAMELA L. Lutsey, JAMES S PANKOW · 1994 to 2026
$9.3M
Promoting Self-Management in Stroke Survivors Using Health ITR21HS021794 · AHRQ · UNIVERSITY OF MINNESOTA · PI LAKSHMINARAYAN, KAMAKSHI · 2012 to 2013
$299k
AHRQ HHS R21 HS021794NHLBI NIH HHS T32 HL007779
6 · The paper itself

Abstract

purposeHypertension (HTN) is significantly under-treated in stroke survivors. We examined usability and efficacy of a mHealth -based care model for improving post-stroke HTN control (Funding: AHRQ R21HS021794).

methodsWe used a RCT design. Planned study duration was 90 days. Intervention arm (IA) participants measured their BP daily using a smart phone and wireless BP monitor. This was transmitted automatically to the study database. Investigators (Physician + PharmD) made bi-weekly medication adjustments to achieve the BP goal. Control arm (CA) participants received a digital BP monitor and usual care. We examined Usability (measured with Marshfield System Usability Survey) and HTN control efficacy using an ITT (intent-to-treat) and as-treated (AT) analyses.

resultsFifty participants (IA = 28; CA = 22) completed the study. The Marshfield survey question, "I thought the system was easy to use" mean score was 4.6, (5 = strongly agree). Mean SBP declined significantly between enrollment and study completion in the IA. In ITT, IA SBP declined 9.88 mm, p = 0.005. In AT, IA SBP declined 10.81 mm, p = 0.0036. CA SBP decline was 5-6 mm Hg (not significant). In the ITT, baseline HTN control (SBP < 140 mm Hg) was 50% in IA and CA. At study completion, HTN was controlled in 82% (23/28) of IA and 64% (14/22) of CA (p = 0.14). In the AT, HTN was controlled in 89% (23/26) of IA and 58% (14/24) of CA, (p = 0.015).

conclusionA mHealth-based HTN care model had excellent usability and provided better HTN control than usual care in stroke survivors. CLINICAL TRIAL: gov: NCT01875094.

Indexed as

Mobile ApplicationsAdultAgedAged, 80 and overAntihypertensive AgentsBlood Pressure Monitoring, AmbulatoryFemaleFollow-Up StudiesHumansHypertensionIntention to Treat AnalysisMaleMedication AdherenceMiddle AgedPilot ProjectsSmartphoneAntihypertensive AgentsHypertensionMHealthSelf-managementStroke survivors

Identifiers

PMID29763657
PMCPMC6317360

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.