Evidence map›Paper›PMID 29763618›Full record

ArticleCancer cell2018

Genomic Features of Response to Combination Immunotherapy in Lung Cancer.

Martin Früh, Solange Peters

Registry-linked trialOpen access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cancer cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04622423 (Advanced Immune Gene and Cell Therapies for Liver Metastases), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04622423 recruitingnot on this mapstarted 2019, after this paper: background citation

Advanced Immune Gene and Cell Therapies for Liver Metastases

TypeobservationalSponsorIRCCS San RaffaeleRan2019 to 2030Enrolled625ConditionsPancreatic Ductal Adenocarcinoma (PDAC), Colorectal Cancer (CRC), Liver Metastasis, IPMN, Pancreatic
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Martin FrühDepartment of Medical Oncology/Hematology, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland.
Solange PetersDepartment of Medical Oncology, University Hospital of Lausanne (CHUV), 1011 Lausanne, Switzerland. Electronic address: solange.peters@chuv.ch.
Kantonsspital St. Gallen · CHUniversity Hospital of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue of Cancer Cell, Hellmann et al. describe in two clinical trials the importance of tumor mutational burden as an independent predictive marker for outcomes with combination nivolumab plus ipilimumab as first-line therapy in metastatic non-small-cell lung cancer and in relapsed small-cell lung cancer.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsAntibodies, MonoclonalGenomicsHumansImmunotherapyNeoplasm Recurrence, LocalAntibodies, Monoclonal

Identifiers

PMID29763618
OpenAlexW2802042719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.