Evidence map›Paper›PMID 29763448›Full record

Trial reportPloS one2018

Modulation of functional activity and connectivity by acupuncture in patients with Alzheimer disease as measured by resting-state fMRI.

Weimin Zheng, Zhuangzhi Su, Xingyun Liu, Hao Zhang, Ying Han, Haiqing Song, Jie Lu, Kuncheng Li, Zhiqun Wang

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Weimin ZhengDepartment of Radiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Zhuangzhi SuDepartment of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China.
Xingyun LiuDepartment of Radiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Hao ZhangDepartment of Radiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Ying HanDepartment of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
Haiqing SongDepartment of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
Jie LuDepartment of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China.
Kuncheng LiDepartment of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China.
Zhiqun WangDepartment of Radiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.ORCID 0000-0001-9608-0962

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acupuncture has been used in the therapy of Alzheimer disease (AD); however, its neural mechanisms are still unclear. The aim of this study is to examine the effect of acupuncture on the functional connectivity in AD by using resting-state functional magnetic resonance imaging (rs-fMRI). Twenty-eight subjects (14 AD and 14 normal controls) participated in this study. The rs-fMRI data were acquired before and after acupuncture stimulation at the acupoints of Tai chong (Liv3) and Hegu (LI4). During the baseline resting state, by using the amplitude of low-frequency fluctuations (ALFF), we found a significantly decreased or increased ALFF in the AD patients relative to the controls. These regions were located in the right superior frontal gyrus (SFG), left postcentral gyrus, subgenual cingulate cortex (SCC), right middle cingulate cortex (MCC), right inferior frontal gyrus (IFG), right hippocampus and the right inferior temporal gyrus (ITG). Then, we selected these brain regions as seeds to investigate whether regional activity and functional connectivity could be modulated by acupuncture in the AD patients. When compared to the pre-acupuncture stage, several of the above regions showed an increased or decreased ALFF after acupuncture in the AD patients. In addition, the functional connectivity between the hippocampus and the precentral gyrus showed enhancement after acupuncture in the AD patients. Finally, there were close correlations between the functional activity, connectivity and clinical performance in the AD patients. The current study confirmed that acupuncture at Tai chong (Liv3) and He gu (LI4) can modulate functional activity and connectivity of specific cognition-related regions in AD patients.

Indexed as

Acupuncture TherapyAlzheimer DiseaseBrainConnectomeMagnetic Resonance ImagingAgedFemaleHumansMaleMiddle Aged

Identifiers

PMID29763448
PMCPMC5953467

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.