ArticleJournal of the American Chemical Society2018
Synthesis, Reactivity, Functionalization, and ADMET Properties of Silicon-Containing Nitrogen Heterocycles.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Recent trends of organic synthesis through cobalt metal-based catalysis: a review.RSC advances · 2026Review
- Iridium-Catalyzed Diorganosilylene Insertion into C(spACS central science · 2026Article
- Palladium-Catalyzed Enantioselective [4 + 2] Annulation with Allenes: Direct Access to Chiral Silatetralins.JACS Au · 2026Article
- Siloxane-spaced salen-type Schiff base cobalt complex. Experimental and docking analysis-a dual approach for evaluating anti-cancer efficacy.Royal Society open science · 2025Article
- Precision installation of silyl synthetic handles within arenes by regiocontrolled ruthenium C(Nature catalysis · 2025Article
- The role of silicon in drug discovery: a review.RSC medicinal chemistry · 2024Review
- Enantioselective Aminosilylation of Alkenes by Palladium/Ming-Phos-Catalyzed Tandem Narasaka-Heck/Silylation Reaction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Nickel-catalyzed, silyl-directed, ortho-borylation of arenes via an unusual Ni(II)/Ni(IV) catalytic cycle.Nature communications · 2024Article
- Surmounting Byproduct Inhibition in an Intermolecular Catalytic Asymmetric Alkene Bromoesterification Reaction as Revealed by Kinetic Profiling.The Journal of organic chemistry · 2023Article
- Visible-light-induced chemo-, diastereo- and enantioselective α-C(spChemical science · 2023Article
- Palladium-catalyzed synthesis of 4-sila-4Chemical science · 2023Article
- Direct synthesis of sila-benzoazoles through hydrosilylation and rearrangement cascade reaction of benzoazoles and silanes.Nature communications · 2023Article
- Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors.Journal of enzyme inhibition and medicinal chemistry · 2022Article
- TheACS medicinal chemistry letters · 2022Article
- Non-enzymatic catalytic asymmetric cyanation of acylsilanes.Communications chemistry · 2022Article
- Ligand relay catalysis for cobalt-catalyzed sequential hydrosilylation and hydrohydrazidation of terminal alkynes.Nature communications · 2022Article
- Silacyclization through palladium-catalyzed intermolecular silicon-based C(spChemical science · 2021Article
- MeChemical science · 2021Article
- Enantioenriched α-Vinyl 1,4-Benzodiazepines and 1,4-Benzoxazepines via Enantioselective Rhodium-Catalyzed Hydrofunctionalizations of Alkynes and Allenes.The Journal of organic chemistry · 2021Article
- Gram-Scale Synthesis of 1,8-Naphthyridines in Water: The Friedlander Reaction Revisited.ACS omega · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Silicon-containing compounds have been largely ignored in drug design and development, despite their potential to improve not only the potency but also the physicochemical and ADMET ( absorption, distribution, metabolism, excretion, toxicity) properties of drug-like candidates because of the unique characteristics of silicon. This deficiency is in large part attributable to a lack of general methods for synthesizing diverse organosilicon structures. Accordingly, a new building block strategy has been developed that diverges from traditional approaches to incorporation of silicon into drug candidates. Flexible, multi-gram-scale syntheses of silicon-containing tetrahydroquinoline and tetrahydroisoquinoline building blocks are described, along with methods by which diversely functionalized silicon-containing nitrogen heterocycles can be rapidly built using common reactions optimized to accommodate the properties of silicon. Furthermore, to better clarify the liabilities and advantages of silicon incorporation, select compounds and their carbon analogues were challenged in ADMET-focused biological studies.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.