Evidence map›Paper›PMID 29762782›Full record

ArticleNucleic acids research2018

MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis.

Jasmine Chong, Othman Soufan, Carin Li, Iurie Caraus, Shuzhao Li, Guillaume Bourque, David S Wishart, Jianguo Xia

2 registry-linked trialsAbstract read
In one paragraph

Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1,872 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,872citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05719714 phase1 / phase2active not recruitingstarted 2024, after this paper: background citation

Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease

Ran2024Enrolled18Registered outcomes5Posted comparisons0ConditionsChronic Kidney Diseases, Heart Failure, Heart Failure With Preserved Ejection Fraction, Kidney DiseasesArmsDapagliflozin 10 MG [Farxiga]
Open the trial in the graph
NCT05808101 terminatednot on this mapstarted 2022, after this paper: background citation

Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects

TypeobservationalSponsorWashington University School of MedicineRan2022 to 2024Enrolled51ConditionsMultiple Sclerosis, DepressionArmsNeuro-QoL T-score determination
3 · Its place in the literature

Who cites it

1,872 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  14. Altitude-Related Adaptation in Freshwater Snails (Animals : an open access journal from MDPI · 2026
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1,812 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jasmine ChongInstitute of Parasitology, McGill University, Montreal, Québec, Canada.
Othman SoufanInstitute of Parasitology, McGill University, Montreal, Québec, Canada.
Carin LiDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Iurie CarausInstitute of Parasitology, McGill University, Montreal, Québec, Canada.
Shuzhao LiDepartment of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Guillaume BourqueCanadian Center for Computational Genomics, McGill University, Montreal, Québec, Canada.
David S WishartDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Jianguo XiaInstitute of Parasitology, McGill University, Montreal, Québec, Canada.

Funding

CIHR
6 · The paper itself

Abstract

We present a new update to MetaboAnalyst (version 4.0) for comprehensive metabolomic data analysis, interpretation, and integration with other omics data. Since the last major update in 2015, MetaboAnalyst has continued to evolve based on user feedback and technological advancements in the field. For this year's update, four new key features have been added to MetaboAnalyst 4.0, including: (1) real-time R command tracking and display coupled with the release of a companion MetaboAnalystR package; (2) a MS Peaks to Pathways module for prediction of pathway activity from untargeted mass spectral data using the mummichog algorithm; (3) a Biomarker Meta-analysis module for robust biomarker identification through the combination of multiple metabolomic datasets and (4) a Network Explorer module for integrative analysis of metabolomics, metagenomics, and/or transcriptomics data. The user interface of MetaboAnalyst 4.0 has been reengineered to provide a more modern look and feel, as well as to give more space and flexibility to introduce new functions. The underlying knowledgebases (compound libraries, metabolite sets, and metabolic pathways) have also been updated based on the latest data from the Human Metabolome Database (HMDB). A Docker image of MetaboAnalyst is also available to facilitate download and local installation of MetaboAnalyst. MetaboAnalyst 4.0 is freely available at http://metaboanalyst.ca.

Indexed as

AlgorithmsUser-Computer InterfaceBiomarkersDatabases, FactualDatasets as TopicHumansMass SpectrometryMetabolic Networks and PathwaysMetabolomeMetabolomicsBiomarkers

Identifiers

PMID29762782
PMCPMC6030889

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.