ArticleMolecular biology and evolution2018
Lipidome Evolution in Mammalian Tissues.
Article in Molecular biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Characterization of Metabolite and Lipid Compositions in Lycopene-Enriched Egg Yolk Using Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry.Foods (Basel, Switzerland) · 2026Article
- Cellular mechanisms of brain lipid metabolism in health and disease.Nature cell biology · 2026Review
- Genomic, molecular, and cellular divergence of the human brain.Trends in neurosciences · 2024Review
- Validation of ferroptosis in canine cancer cells to enable comparative oncology and translational medicine.bioRxiv : the preprint server for biology · 2024Article
- Article
- Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain.Antioxidants (Basel, Switzerland) · 2023Review
- Article
- Dietary supplements in neurological diseases and brain aging.Journal of preventive medicine and hygiene · 2022Review
- Modular Evolution of the Drosophila Metabolome.Molecular biology and evolution · 2022Article
- Age-Related Changes in Lipidome of Rat Frontal Cortex and Cerebellum Are Partially Reversed by Methionine Restriction Applied in Old Age.International journal of molecular sciences · 2021Article
- A deep dive into fat: Investigating blubber lipidomic fingerprint of killer whales and humpback whales in northern Norway.Ecology and evolution · 2021Article
- The Lipidome Fingerprint of Longevity.Molecules (Basel, Switzerland) · 2020Review
- Impact of Plasma Membrane Domains on IgG Fc Receptor Function.Frontiers in immunology · 2020Review
- Differences in lipidome and metabolome organization of prefrontal cortex among human populations.Scientific reports · 2019Article
- Article
- Lipidomics Reveals a Tissue-Specific Fingerprint.Frontiers in physiology · 2018Article
- Aging, VOIndian journal of pharmacologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipids are essential structural and functional components of cells. Little is known, however, about the evolution of lipid composition in different tissues. Here, we report a large-scale analysis of the lipidome evolution in six tissues of 32 species representing primates, rodents, and bats. While changes in genes' sequence and expression accumulate proportionally to the phylogenetic distances, <2% of the lipidome evolves this way. Yet, lipids constituting this 2% cluster in specific functions shared among all tissues. Among species, human show the largest amount of species-specific lipidome differences. Many of the uniquely human lipidome features localize in the brain cortex and cluster in specific pathways implicated in cognitive disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.