ArticleNucleic acids research2018
AAI-profiler: fast proteome-wide exploratory analysis reveals taxonomic identity, misclassification and contamination.
Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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76 citing papers in PubMed.
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- Pseudomonas eutrophicaquae sp. nov., a novel xenobiotic-degrading non-motile bacterium, containing Q-8 ubiquinone, isolated from an aquatic ecosystem in Jimo District, China.Antonie van Leeuwenhoek · 2026Article
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- Lotipaludicoccus stagni gen. nov., sp. nov., within the Family Opitutaceae, Isolated from a Lotus Wetland.Current microbiology · 2025Article
- Phaeovulum Molybdatiresistens sp. nov., a Molybdate-resistant Bacterium Isolated from Eutrophic Pond Water.Current microbiology · 2025Article
- PSK1, a bacteriophage with antibacterial activity against extended-spectrum-beta-lactamase-producing Escherichia coli sequence type 131 with serotype O25:H4.Archives of virology · 2025Article
- Phenotypic and omics analyses of the SordariomycetesmSystems · 2025Article
- Idiomarina aminovorans sp. nov., a halophilic bacterium isolated from the Llamara salt pan in the Atacama Desert of northern Chile.Extremophiles : life under extreme conditions · 2025Article
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- Meridianimarinicoccus marinus sp. nov., Isolated from Tidal Flat.Current microbiology · 2025Article
- ABP-B9, a new strain ofFrontiers in plant science · 2025Article
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- Delineating bacterial genera based on gene content analysis: a case study of theMicrobial genomics · 2024Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present AAI-profiler, a web server for exploratory analysis and quality control in comparative genomics. AAI-profiler summarizes proteome-wide sequence search results to identify novel species, assess the need for taxonomic reclassification and detect multi-isolate and contaminated samples. AAI-profiler visualises results using a scatterplot that shows the Average Amino-acid Identity (AAI) from the query proteome to all similar species in the sequence database. Taxonomic groups are indicated by colour and marker styles, making outliers easy to spot. AAI-profiler uses SANSparallel to perform high-performance homology searches, making proteome-wide analysis possible. We demonstrate the efficacy of AAI-profiler in the discovery of a close relationship between two bacterial symbionts of an omnivorous pirate bug (Orius) and a thrip (Frankliniella occidentalis), an important pest in agriculture. The symbionts represent novel species within the genus Rosenbergiella so far described only in floral nectar. AAI-profiler is easy to use, the analysis presented only required two mouse clicks and was completed in a few minutes. AAI-profiler is available at http://ekhidna2.biocenter.helsinki.fi/AAI.
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