Evidence map›Paper›PMID 29762697›Full record

ArticleJournal of Crohn's & colitis2018

Sarcopenia is a Novel Predictor of the Need for Rescue Therapy in Hospitalized Ulcerative Colitis Patients.

Kelly C Cushing, Hamed Kordbacheh, Michael S Gee, Avinash Kambadakone, Ashwin N Ananthakrishnan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Crohn's & colitis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 7 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 7 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kelly C CushingDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Hamed KordbachehHarvard Medical School, Boston, MA, USA.
Michael S GeeHarvard Medical School, Boston, MA, USA.
Avinash KambadakoneHarvard Medical School, Boston, MA, USA.
Ashwin N AnanthakrishnanDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Massachusetts General Hospital · USHarvard University · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Genetic predictors of calprotectin response with anti-TNF and anti-integrin therapy in inflammatory bowel diseasesR03DK112909 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ANANTHAKRISHNAN, ASHWIN N · 2017 to 2018
$171k
NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R03 DK112909
6 · The paper itself

Abstract

BACKGROUND AND

aimsAcute severe ulcerative colitis [ASUC] affects one in four patients with UC. Clinical parameters perform modestly in predicting the need for rescue therapy. Sarcopenia and visceral adiposity predict natural history in Crohn's disease, but the role of such metabolic factors on ASUC outcomes is unknown. The aim of this study was to define the effect of sarcopenia and visceral adiposity on outcomes in ASUC.

methodsWe studied patients hospitalized for ASUC who underwent an abdominal CT scan during the hospitalization. Quantification of skeletal muscle mass and visceral adiposity was performed by radiologists blinded to the outcome. Sarcopenia was defined as a skeletal muscle index of <55 cm2/m2 for men and <39 cm2/m2 for women. The primary outcome of interest was need for medical or surgical rescue therapy.

resultsOur study included 89 patients with ASUC, among whom 39 [43.8%] patients required medical rescue therapy or surgery. Two-thirds of the cohort [70%] met the definition of sarcopenia [81% men, 48% women]. Patients with sarcopenia had similar disease characteristics and laboratory parameters to those with a normal muscle mass. However, a larger proportion of patients with sarcopenia required rescue therapy compared with those without (56% vs 28%, multivariable odds ratio [OR] 3.98, 95% confidence interval [CI] 1.12-14.1). Neither visceral [p = 0.23] nor subcutaneous adiposity [p = 0.53] predicted the need for rescue therapy.

conclusionsSarcopenia as determined on abdominal CT was a novel predictor of need for rescue therapy in hospitalized UC patients.

Indexed as

AdiposityAdolescentAdultAgedAged, 80 and overBody Mass IndexChildColectomyColitis, UlcerativeFemaleHospitalizationHumansIntra-Abdominal FatMaleMiddle AgedRetrospective StudiescolectomySarcopeniaulcerative colitis

Identifiers

PMID29762697
PMCPMC6113707
OpenAlexW2800653353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.