Evidence map›Paper›PMID 29762657›Full record

ArticleAmerican journal of epidemiology2018

Prospects for Tuberculosis Elimination in the United States: Results of a Transmission Dynamic Model.

Nicolas A Menzies, Ted Cohen, Andrew N Hill, Reza Yaesoubi, Kara Galer, Emory Wolf, Suzanne M Marks, Joshua A Salomon

Erratum issuedAbstract read
In one paragraph

Article in American journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. A model for the epidemiological impact of tuberculosis policy options.Bulletin of the World Health Organization · 2026
    Article
  5. Uncovering Household Tuberculosis Infection Testing and Care Patterns Using a Novel Bioinformatics Linkage Strategy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  6. Effects of the COVID-19 Pandemic on Tuberculosis Outcomes in the United States: A Bayesian Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. ThemedRxiv : the preprint server for health sciences · 2025
    Article
  12. Article
  13. Article
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  15. Article
  16. Symptoms and Systemic Drug Reactions in Persons Receiving Weekly Rifapentine Plus Isoniazid (3HP) Treatment for Latent Tuberculosis Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  17. Article
  18. Using the Food and Drug Administration´s Sentinel System for surveillance of TB infection.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022
    Article
  19. Evaluation of the Latent Tuberculosis Care Cascade Among Public Health Clinics in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Nicolas A MenziesDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Ted CohenDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut.
Andrew N HillDivision of TB Elimination, US Centers for Disease Control and Prevention, Atlanta, Georgia.
Reza YaesoubiDepartment of Health Policy & Management, Yale School of Public Health, New Haven, Connecticut.
Kara GalerDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Emory WolfDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Suzanne M MarksDivision of TB Elimination, US Centers for Disease Control and Prevention, Atlanta, Georgia.
Joshua A SalomonDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Funding

Economic Modeling for HIV, Viral Hepatitis, STD, TB and School HealthU38PS004644 · PS · HARVARD SCHOOL OF PUBLIC HEALTH · PI SALOMON, JOSHUA A · 2014 to 2015
$2.9M
Improving the control of multidrug-resistant tuberculosis through targeted screening and use of novel anti-tuberculosis drugsK01AI119603 · NIAID · YALE UNIVERSITY · PI YAESOUBI, REZA · 2016 to 2019
$518k
Intramural CDC HHS CC999999NCHHSTP CDC HHS U38 PS004644NIAID NIH HHS K01 AI119603
6 · The paper itself

Abstract

We estimated long-term tuberculosis (TB) trends in the US population and assessed prospects for TB elimination. We used a detailed simulation model allowing for changes in TB transmission, immigration, and other TB risk determinants. Five hypothetical scenarios were evaluated from 2017 to 2100: 1) maintain current TB prevention and treatment activities (base case); 2) provision of latent TB infection testing and treatment for new legal immigrants; 3) increased uptake of latent TB infection screening and treatment among high-risk populations, including a 3-month isoniazid-rifapentine regimen; 4) improved TB case detection; and 5) improved TB treatment quality. Under the base case, we estimate that by 2050, TB incidence will decline to 14 cases per million, a 52% (95% posterior interval (PI): 35, 67) reduction from 2016, and 82% (95% posterior interval: 78, 86) of incident TB will be among persons born outside of the United States. Intensified TB control could reduce incidence by 77% (95% posterior interval: 66, 85) by 2050. We predict TB may be eliminated in US-born but not non-US-born persons by 2100. Results were sensitive to numbers of people entering the United States with latent or active TB, and were robust to alternative interpretations of epidemiologic evidence. TB elimination in the United States remains a distant goal; however, strengthening TB prevention and treatment could produce important health benefits.

Indexed as

Disease EradicationModels, TheoreticalHumansTuberculosisUnited States

Identifiers

PMID29762657
PMCPMC6119121

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.