ReviewNutrients2018
Insulin Sensitivity and Glucose Homeostasis Can Be Influenced by Metabolic Acid Load.
Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03790579 (Is There Any Effect of Maternal Dietary Acid Load During Pregnancy on Arising Gestational Diabetes Mellitus?), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is There Any Effect of Maternal Dietary Acid Load During Pregnancy on Arising Gestational Diabetes Mellitus?
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Association between dietary acid load and risk of osteoporotic fractures in adults: a systematic review and meta-analysis of observational studies.BMC musculoskeletal disorders · 2025Pooled it
- Dietary Acid Load and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies.Frontiers in nutrition · 2022Pooled it
- Combination of Texture-Induced Oral Processing and Vegetable Preload Strategy Reduced Glycemic Excursion but Decreased Insulin Sensitivity.Nutrients · 2022Trial
- Microvascular Complications of Food Insecurity in a Vulnerable Patient Population.Diseases (Basel, Switzerland) · 2026Article
- Association Between Albumin-Corrected Anion Gap and Prevalent Prediabetes or Diabetes Mellitus: A Cross-Sectional Analysis of NHANES 2005-2010.Journal of diabetes research · 2026Article
- Fat deposition and growth performance in broiler chickens are diversely influenced by maize or wheat following dietary crude protein reductions plausibly involving insulin.Journal of animal science and biotechnology · 2025Review
- Beyond Thirst: Influence of Bicarbonate Mineral Water on Cardiovascular Risk Factors, Gastrointestinal Function, and Liver Health.Food science & nutrition · 2025Review
- Attrition of amino acids in the life span of broiler chickens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Review
- A perception that the feed grain basis of reduced-crude protein diets modifies the anabolic impact of insulin on the growth performance of broiler chickens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Review
- The association between dietary acid load and indices of insulin resistance.Scientific reports · 2025Article
- Effects of higher dietary acid load: a narrative review with special emphasis in children.Pediatric nephrology (Berlin, Germany) · 2025Review
- Relationship between dietary acid-base load and non-insulin-based resistance measures in patients with chronic kidney disease.Frontiers in endocrinology · 2025Article
- Effects of Preanhepatic Glucose-Insulin Infusion on Metabolic and Hemodynamic Outcomes in Liver Transplantation: A Randomized Clinical Trial : Preanhepatic Glucose-Insulin Infusion and Liver Transplantation.Galen medical journal · 2025Article
- International dietary quality index and its association with diabetes in RaNCD cohort study.Scientific reports · 2024Article
- Nutritional Strategies to Prevent Muscle Loss and Sarcopenia in Chronic Kidney Disease: What Do We Currently Know?Nutrients · 2023Review
- Insulin Resistance and Urolithiasis as a Challenge for a Dietitian.International journal of environmental research and public health · 2022Review
- The Role of Dietary Intake in Type 2 Diabetes Mellitus: Importance of Macro and Micronutrients in Glucose Homeostasis.Nutrients · 2022Article
- Oral Acid Load Down-Regulates Fibroblast Growth Factor 23.Nutrients · 2022Article
- Healthy Aging and Dietary Patterns.Nutrients · 2022Review
- Can Overnutrition Lead to Wasting?-The Paradox of Diabetes Mellitus in End-Stage Renal Disease Treated with Maintenance Hemodialysis.Nutrients · 2022Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent epidemiological findings suggest that high levels of dietary acid load can affect insulin sensitivity and glucose metabolism. Consumption of high protein diets results in the over-production of metabolic acids which has been associated with the development of chronic metabolic disturbances. Mild metabolic acidosis has been shown to impair peripheral insulin action and several epidemiological findings suggest that metabolic acid load markers are associated with insulin resistance and impaired glycemic control through an interference intracellular insulin signaling pathways and translocation. In addition, higher incidence of diabetes, insulin resistance, or impaired glucose control have been found in subjects with elevated metabolic acid load markers. Hence, lowering dietary acid load may be relevant for improving glucose homeostasis and prevention of type 2 diabetes development on a long-term basis. However, limitations related to patient acid load estimation, nutritional determinants, and metabolic status considerably flaws available findings, and the lack of solid data on the background physiopathology contributes to the questionability of results. Furthermore, evidence from interventional studies is very limited and the trials carried out report no beneficial results following alkali supplementation. Available literature suggests that poor acid load control may contribute to impaired insulin sensitivity and glucose homeostasis, but it is not sufficiently supportive to fully elucidate the issue and additional well-designed studies are clearly needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.