Evidence map›Paper›PMID 29762469›Full record

ArticleJournal of clinical medicine2018

Individualised Multimodal Treatment Strategies for Anaplastic and Poorly Differentiated Thyroid Cancer.

Sabine Wächter, Annette Wunderlich, Silvia Roth, Ioannis Mintziras, Elisabeth Maurer, Sebastian Hoffmann, Frederik A Verburg, Sebastian A Fellinger, Katharina Holzer, Detlef K Bartsch and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. [Personalized approach to anaplastic thyroid carcinoma].Chirurgie (Heidelberg, Germany) · 2024
    Review
  6. Review
  7. The role of miR-139-5p in radioiodine-resistant thyroid cancer.Journal of endocrinological investigation · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Poorly Differentiated Carcinoma of the Thyroid Gland: Current Status and Future Prospects.Thyroid : official journal of the American Thyroid Association · 2019
    Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sabine WächterDepartment of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, D-35043 Marburg, Germany. seckhard@med.uni-marburg.de.
Annette WunderlichDepartment of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, D-35043 Marburg, Germany. wunderli.an@gmail.com.
Silvia RothDepartment of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, D-35043 Marburg, Germany. rothsi@med.uni-marburg.de.
Ioannis MintzirasDepartment of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, D-35043 Marburg, Germany. ioannis.mintziras@uk-gm.de.
Elisabeth MaurerDepartment of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, D-35043 Marburg, Germany. maurere@med.uni-marburg.de.
Sebastian HoffmannDepartment of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, D-35043 Marburg, Germany. chirurgie@mkh-bgl.de.
Frederik A VerburgDepartment of Nuclear Medicine, Philipps University Marburg, Baldingerstrasse, D-35043 Marburg, Germany. frederikanton.verburg@uk-gm.de.
Sebastian A FellingerDepartment of Nuclear Medicine, Philipps University Marburg, Baldingerstrasse, D-35043 Marburg, Germany. sebastian.fellinger@med.uni-marburg.de.
Katharina HolzerDepartment of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, D-35043 Marburg, Germany. katharina.holzer@uk-gm.de.
Detlef K BartschDepartment of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, D-35043 Marburg, Germany. bartsch@med.uni-marburg.de.
Pietro Di FazioDepartment of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, D-35043 Marburg, Germany. difazio@med.uni-marburg.de.
Philipps University of Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prognosis of anaplastic (ATC) and poorly differentiated thyroid cancer (PDTC) is poor, due to their radioiodine refractoriness (RAI-R), high metastatic potential and current lack of effective treatment strategies. We aimed to examine the efficacy of the tyrosine kinase inhibitors (TKIs) sorafenib and selumetinib and the histone deacetylase inhibitor (HDACI) panobinostat in patient-derived tumor tissue (PDTT) of ATCs/PDTCs, the expression of sodium iodide symporter (

Indexed as

anaplastic thyroid cancerepigeneticshistone deacetylase inhibitorsHMGA2miRNAspoorly differentiated thyroid cancersodium iodide symportertyrosine kinase inhibitors

Identifiers

PMID29762469
PMCPMC5977154
OpenAlexW2804878094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.