ArticleJournal of pediatric gastroenterology and nutrition2018
13C-Labeled-Starch Breath Test in Congenital Sucrase-isomaltase Deficiency.
Article in Journal of pediatric gastroenterology and nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- European guideline on indications, performance and clinical impact ofUnited European gastroenterology journal · 2021Guideline
- Associations ofCurrent developments in nutrition · 2025Article
- Stunted African toddlers digest and obtain energy from energy-dense thick sorghum porridge.European journal of clinical nutrition · 2025Article
- Little Patients Big Discoveries: Potential Pediatric to Adult Neurogastroenterology Translation.The American journal of gastroenterology · 2025Review
- A cross-sectional study of associations between theThe American journal of clinical nutrition · 2024Observational
- Performance of empirical and model-based classifiers for detecting sucrase-isomaltase inhibition using theJournal of breath research · 2024Article
- Congenital Sucrase-Isomaltase Deficiency: Same Mutation with Different Clinical Presentations.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Article
- An Update on the Assessment and Management of Pediatric Abdominal Pain.Pediatric health, medicine and therapeutics · 2021Review
- Article
- The Role of Disaccharidase Deficiencies in Functional Abdominal Pain Disorders-A Narrative Review.Nutrients · 2018Review
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Authors and funding
7 authors.
Funding
Abstract
background and hypothesesHuman starch digestion is a multienzyme process involving 6 different enzymes: salivary and pancreatic α-amylase; sucrase and isomaltase (from sucrose-isomaltase [SI]), and maltase and glucoamylase (from maltase-glucoamylase [MGAM]). Together these enzymes cleave starch to smaller molecules ultimately resulting in the absorbable monosaccharide glucose. Approximately 80% of all mucosal maltase activity is accounted for by SI and the reminder by MGAM. Clinical studies suggest that starch may be poorly digested in those with congenital sucrase-isomaltase deficiency (CSID). Poor starch digestion occurs in individuals with CSID and can be documented using a noninvasive C-breath test (BT).
methodsC-Labled starch was used as a test BT substrate in children with CSID. Sucrase deficiency was previously documented in study subjects by both duodenal biopsy enzyme assays and C-sucrose BT. Breath CO2 was quantitated at intervals before and after serial C-substrate loads (glucose followed 75 minutes later by starch). Variations in metabolism were normalized against C-glucose BT (coefficient of glucose absorption). Control subjects consisted of healthy family members and a group of children with functional abdominal pain with biopsy-proven sucrase sufficiency.
resultsChildren with CSID had a significant reduction of C-starch digestion mirroring that of their duodenal sucrase and maltase activity and C-sucrase BT.
conclusionsIn children with CSID, starch digestion may be impaired. In children with CSID, starch digestion correlates well with measures of sucrase activity.
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