Evidence map›Paper›PMID 29762166›Full record

ArticleAIDS (London, England)2018

Undisclosed antiretroviral drug use in Botswana: implication for national estimates.

Sikhulile Moyo, Simani Gaseitsiwe, Kathleen M Powis, Molly Pretorius Holme, Terence Mohammed, Melissa Zahralban-Steele, Etienne K Yankinde, Comfort Maphorisa, William Abrams, Refeletswe Lebelonyane and 10 more

Registry-linked trialAbstract read
In one paragraph

Article in AIDS (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01965470 (Botswana Combination Prevention Project), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01965470 phase4completednot on this map

Botswana Combination Prevention Project: -Evaluation Protocol (Protocol #1): Research Design and Impact Evaluation -Closed Clinical Cohort Protocol (Protocol #3) Implementation, Monitoring and Evaluation of Combination HIV Prevention Interventions in Rural and Peri-Urban Communities in Botswana

TypeinterventionalSponsorCenters for Disease Control and PreventionRan2013 to 2018ConditionsHIVArmsCombination Prevention, Enhanced Care
3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Pharmacology of HIV Cure: Site of Action.Clinical pharmacology and therapeutics · 2021
    Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Sikhulile MoyoBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Simani GaseitsiweBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Kathleen M PowisBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Molly Pretorius HolmeBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Terence MohammedBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Melissa Zahralban-SteeleHarvard T.H. Chan School of Public Health.
Etienne K YankindeBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Comfort MaphorisaBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
William AbramsCDC Botswana.
Refeletswe LebelonyaneBotswana Ministry of Health and Wellness, Gaborone, Botswana.
Kutlo ManyakeBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Tumalano SekotoBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Mompati MmalaneBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Tendani GaolatheBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Kathleen E WirthHarvard T.H. Chan School of Public Health.
Joseph MakhemaBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Shahin LockmanBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
William ClarkeJohns Hopkins Hospital, Baltimore, Maryland, USA.
Max EssexBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Vlad NovitskyBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.

Funding

Partnership for Global Health Research Training Program (Renewal)-Supplement for OBSSR, NCI, NCI-AIDS and NIDCDD43TW010543 · FIC · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Wafaie W Fawzi, DAVIDSON HOWES HAMER · 2017 to 2026
$12.1M
Mentoring in Patient-Oriented HIV Research in the Era of Universal ARTK24AI131928 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAHIN LOCKMAN · 2017 to 2026
$1.9M
CGH CDC HHS U01 GH000447CGH CDC HHS U2G GH001911FIC NIH HHS D43 TW010543NIAID NIH HHS K24 AI131928PEPFARWellcome TrustWellcome Trust 107752/Z/15/Z
6 · The paper itself

Abstract

: Among 3596 HIV-positive participants enrolled in the Botswana Combination Prevention Project who self-reported no prior antiretroviral (ARV) therapy use and were tested for viral load (n = 951; 27% of all participants), 136 (14%) had HIV-1 RNA less than 400 copies/ml. ARV drugs were detected in 52 (39%) of 134 participants tested. Adjusting for undisclosed ARV use increased the overall estimate of virally suppressed individuals on ARV therapy by 1.4% from 70.2 to 71.6%.

Indexed as

Viral LoadAdolescentAdultAnti-Retroviral AgentsBotswanaFemaleHIV-1HIV InfectionsHumansMaleMiddle AgedRNA, ViralTreatment OutcomeYoung AdultAnti-Retroviral AgentsRNA, Viral

Identifiers

PMID29762166
PMCPMC6047897

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.