Evidence map›Paper›PMID 29762136›Full record

ArticlePhysics in medicine and biology2018

Evaluation of a clinical TOF-PET detector design that achieves ⩽100 ps coincidence time resolution.

Joshua W Cates, Craig S Levin

Abstract readEvaluation Study
In one paragraph

Article in Physics in medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Development of Whole-Body TOF-DOI PET Detector Using Dual-Ended Readout Method.IEEE transactions on instrumentation and measurement · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Timing Estimation and Limits in TOF-PET Detectors Producing Prompt Photons.IEEE transactions on radiation and plasma medical sciences · 2023
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. TOF-PET Image Reconstruction With Multiple Timing Kernels Applied on Cherenkov Radiation in BGO.IEEE transactions on radiation and plasma medical sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joshua W CatesDepartment of Radiology, Stanford University, Stanford, CA, United States of America.
Craig S LevinDepartment of Radiology, Stanford University, Stanford, CA, United States of America.

Funding

Stanford Molecular Imaging Scholars - SMISR25CA118681 · NCI · STANFORD UNIVERSITY · PI LEVIN, CRAIG S · 2006 to 2015
$5.0M
Stanford Molecular Imaging Scholars (SMIS) ProgramT32CA118681 · NCI · STANFORD UNIVERSITY · PI CRAIG S LEVIN · 2016 to 2026
$4.3M
Exploring a promising design for the next generation time-of-flight PET detectorR01CA214669 · NCI · STANFORD UNIVERSITY · PI LEVIN, CRAIG S · 2017 to 2021
$2.9M
A new direction to achieve ultra-fast timing for positron emission tomographyR01EB023903 · NIBIB · STANFORD UNIVERSITY · PI LEVIN, CRAIG S · 2017 to 2020
$2.5M
Technologies to drastically boost photon sensitivity for brain-dedicated PETR01EB025125 · NIBIB · STANFORD UNIVERSITY · PI LEVIN, CRAIG S · 2017 to 2018
$984k
NCI NIH HHS R01 CA214669NCI NIH HHS R25 CA118681NCI NIH HHS T32 CA118681NIBIB NIH HHS R01 EB023903NIBIB NIH HHS R01 EB025125
6 · The paper itself

Abstract

Commercially available clinical positron emission tomography (PET) detectors employ scintillation crystals that are long ([Formula: see text]20 mm length) and narrow (4-5 mm width) optically coupled on their narrow end to a photosensor. The aspect ratio of this traditional crystal rod configuration and 511 keV photon attenuation properties yield significant variances in scintillation light collection efficiency and transit time to the photodetector, due to variations in the 511 keV photon interaction depth in the crystal. These variances contribute significant to coincidence time resolution degradation. If instead, crystals are coupled to a photosensor on their long side, near-complete light collection efficiency can be achieved, and scintillation photon transit time jitter is reduced. In this work, we compare the achievable coincidence time resolution (CTR) of LGSO:Ce(0.025 mol%) crystals 3-20 mm in length when optically coupled to silicon photomultipliers (SiPMs) on either their short end or long side face. In this 'side readout' configuration, a CTR of 102  ±  2 ps FWHM was measured with [Formula: see text] mm

Indexed as

PhotonsElectronicsHumansPositron-Emission TomographyScintillation CountingSensitivity and Specificity

Identifiers

PMID29762136
PMCPMC6016378

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.