Evidence map›Paper›PMID 29762122›Full record

ArticleeLife2018

Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish.

Almary Guerra, Raoul Fv Germano, Oliver Stone, Rima Arnaout, Stefan Guenther, Suchit Ahuja, Verónica Uribe, Benoit Vanhollebeke, Didier Yr Stainier, Sven Reischauer

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. The Interaction Between theInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Science advances · 2024
    Article
  8. Control of cardiac contractions using Cre-lox and degron strategies in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Evolutionary Aspects of Chamber Formation and Septation.Advances in experimental medicine and biology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Getting to the Heart of Left-Right Asymmetry: Contributions from the Zebrafish Model.Journal of cardiovascular development and disease · 2021
    Review
  19. Persistent Ventricle Partitioning in the Adult Zebrafish Heart.Journal of cardiovascular development and disease · 2021
    Article
  20. From Stripes to a Beating Heart: Early Cardiac Development in Zebrafish.Journal of cardiovascular development and disease · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Almary Guerra *Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.ORCID 0000-0002-5080-9559
Raoul Fv Germano *Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.ORCID 0000-0002-1247-0689
Oliver StoneDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Rima ArnaoutDivision of Cardiology, Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, United States.
Stefan GuentherECCPS Bioinformatics and Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Suchit AhujaDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Verónica UribeDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Benoit VanhollebekeLaboratory of Neurovascular Signaling, Department of Molecular Biology, ULB Neuroscience Institute, Université libre de Bruxelles, Bruxelles, Belgium.
Didier Yr StainierDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.ORCID 0000-0002-0382-0026
Sven ReischauerDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.ORCID 0000-0002-6955-9481

Funding

MOLECULAR GENETICS OF CARDIAC CELL DIFFERENTIATIONR01HL054737 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COUGHLIN, SHAUN R. · 1996 to 2015
$5.4M
Genetics and Structure of Trabecular Myocardium in Development and DiseaseK08HL125945 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARNAOUT, RIMA · 2015 to 2019
$863k
NHLBI NIH HHS K08 HL125945NHLBI NIH HHS R01 HL054737NIH HHS HL54737NIH HHS K08HL125945
6 · The paper itself

Abstract

The ultimate formation of a four-chambered heart allowing the separation of the pulmonary and systemic circuits was key for the evolutionary success of tetrapods. Complex processes of cell diversification and tissue morphogenesis allow the left and right cardiac compartments to become distinct but remain poorly understood. Here, we describe an unexpected laterality in the single zebrafish atrium analogous to that of the two atria in amniotes, including mammals. This laterality appears to derive from an embryonic antero-posterior asymmetry revealed by the expression of the transcription factor gene

Indexed as

OrganogenesisAnimalsBody PatterningGene Expression Regulation, DevelopmentalHeartHomeodomain ProteinsZebrafishZebrafish ProteinsHomeodomain Proteinsmeis2b protein, zebrafishZebrafish Proteinsdevelopmental biologyheart developmentleft-right asymmetrymeis2morphogenesismousestem cellszebrafish

Identifiers

PMID29762122
PMCPMC5953537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.