Evidence map›Paper›PMID 29762052›Full record

SynthesisChildhood obesity (Print)

Effects of Physical Exercise on Adiponectin, Leptin, and Inflammatory Markers in Childhood Obesity: Systematic Review and Meta-Analysis.

Felice Sirico, Antonio Bianco, Giovanni D'Alicandro, Clotilde Castaldo, Stefania Montagnani, Rocco Spera, Franca Di Meglio, Daria Nurzynska

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Childhood obesity (Print). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 9 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 9 syntheses or guidelines pooled it, 175 citations in OpenAlex.

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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Felice Sirico1 Department of Public Health, Human Anatomy, and Sports Medicine Section, University of Naples "Federico II ," Naples, Italy .
Antonio Bianco1 Department of Public Health, Human Anatomy, and Sports Medicine Section, University of Naples "Federico II ," Naples, Italy .
Giovanni D'Alicandro2 Department of Neuroscience and Rehabilitation, Centre for Sports Medicine and Disability, Santobono-Pausilipon Children's Hospital , Naples, Italy .
Clotilde Castaldo1 Department of Public Health, Human Anatomy, and Sports Medicine Section, University of Naples "Federico II ," Naples, Italy .
Stefania Montagnani1 Department of Public Health, Human Anatomy, and Sports Medicine Section, University of Naples "Federico II ," Naples, Italy .
Rocco Spera1 Department of Public Health, Human Anatomy, and Sports Medicine Section, University of Naples "Federico II ," Naples, Italy .
Franca Di Meglio1 Department of Public Health, Human Anatomy, and Sports Medicine Section, University of Naples "Federico II ," Naples, Italy .
Daria Nurzynska1 Department of Public Health, Human Anatomy, and Sports Medicine Section, University of Naples "Federico II ," Naples, Italy .
Federico II University Hospital · ITUniversity of Naples Federico II · ITSantobono Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNew findings on adipose tissue physiology and obesity-associated inflammation status suggest that modification of the adipokine level can be relevant for the long-term prevention of obesity-associated chronic disease.

objectivesThe scope of the present study was to investigate the effectiveness of physical exercise in reducing the systemic inflammation related to obesity in children.

methodsWe conducted a systematic review with meta-analysis of controlled randomized trials, identified through electronic database search, which investigated the effect of physical exercise, without concomitant dietary intervention, on adiponectin, leptin, and/or other inflammatory markers in children up to age 18 years with a body mass index greater than the 95th percentile for age and sex.

resultsSeven trials were included in the meta-analysis, with a total of 250 participants. Compared with the control group without any lifestyle modification, the physical exercise resulted in a reduction in leptin [standardized mean difference (SMD) -1.13; 95% confidence interval (95%CI): -1.89 to -0.37; I

conclusionsThese results indicate that physical exercise improved the inflammatory state in children with obesity. It is unclear whether this effect can reduce the risk of cardiovascular and metabolic disease in adulthood. Clinical trials with a uniform intervention protocol and outcome measurements are required to put our knowledge on adipose tissue biology into a clinical perspective.

Indexed as

AdiponectinBiomarkersChildExerciseHumansInflammation MediatorsLeptinPediatric ObesityRandomized Controlled Trials as TopicAdiponectinADIPOQ protein, humanBiomarkersInflammation MediatorsLeptinadiponectinchildhood obesityinflammationleptinphysical exercise

Identifiers

PMID29762052
PMCPMC5994661
OpenAlexW2808131459

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.