ArticleJournal of the American Chemical Society2018
Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed.
- Condensation-independent intramodular translocation mechanism of the trans-AT polyketide synthase assembly line.Nature chemical biology · 2026Article
- C-terminal dimerization motifs control asynchronous chain elongation during modular polyketide biosynthesis.The Journal of biological chemistry · 2026Article
- Ancestral sequence reconstruction as a tool for structural analysis of modular polyketide synthases.Nature communications · 2025Article
- Structural basis for intermodular communication in assembly-line polyketide biosynthesis.Nature chemical biology · 2025Article
- Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2.Natural product reports · 2024Review
- Structure and Mechanisms of Assembly-Line Polyketide Synthases.Annual review of biochemistry · 2024Review
- Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase.Biochemistry · 2023Article
- Enzymology of assembly line synthesis by modular polyketide synthases.Nature chemical biology · 2023Review
- Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry.Structure (London, England : 1993) · 2022Article
- Fragment antigen binding domains (FSynthetic and systems biotechnology · 2022Article
- Article
- HowACS chemical biology · 2021Article
- Modular polyketide synthase contains two reaction chambers that operate asynchronously.Science (New York, N.Y.) · 2021Article
- Mapping the catalytic conformations of an assembly-line polyketide synthase module.Science (New York, N.Y.) · 2021Article
- Recent trends in biocatalysis.Chemical Society reviews · 2021Review
- Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Synthetic biology enabling access to designer polyketides.Current opinion in chemical biology · 2020Review
- Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction.Journal of the American Chemical Society · 2020Article
- Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis.Nature chemistry · 2020Article
- Challenges and opportunities for engineering assembly-line polyketide biosynthesis inMetabolic engineering communications · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Catalytic modules of assembly-line polyketide synthases (PKSs) have previously been observed in two very different conformations-an "extended" architecture and an "arch-shaped" architecture-although the catalytic relevance of neither has been directly established. By the use of a fully human naïve antigen-binding fragment (F
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Registered trials
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