ArticleJournal of the American Chemical Society2018
The Role of Structural Enthalpy in Spherical Nucleic Acid Hybridization.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Spherical Nucleic Acids: Turning Synthetic Advances and Fundamental Discovery into Translational Breakthroughs in Chemistry, Materials Development, Biology, and Medicine.Accounts of chemical research · 2026Article
- POSA for fast, amplified and multiplexed protein imaging.Nature communications · 2025Article
- Early warning ofiScience · 2022Article
- Poly-adenine-mediated spherical nucleic acids for interfacial recognition of kanamycin.Mikrochimica acta · 2022Article
- Synthesis of an Azide- and Tetrazine-Functionalized [60]Fullerene and Its Controlled Decoration with Biomolecules.ACS omega · 2022Article
- Spherical Nucleic Acids: Integrating Nanotechnology Concepts into General Chemistry Curricula.Journal of chemical education · 2021Article
- Controlled Monofunctionalization of Molecular Spherical Nucleic Acids on a Buckminster Fullerene Core.Bioconjugate chemistry · 2021Article
- From predictive modelling to machine learning and reverse engineering of colloidal self-assembly.Nature materials · 2021Review
- Engineering DNA-Functionalized Nanostructures to Bind Nucleic Acid Targets Heteromultivalently with Enhanced Avidity.Journal of the American Chemical Society · 2020Article
- Engineering base-excised aptamers for highly specific recognition of adenosine.Chemical science · 2020Article
- The effector mechanism of siRNA spherical nucleic acids.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
DNA hybridization onto DNA-functionalized nanoparticle surfaces (e.g., in the form of a spherical nucleic acid (SNA)) is known to be enhanced relative to hybridization free in solution. Surprisingly, via isothermal titration calorimetry, we reveal that this enhancement is enthalpically, as opposed to entropically, dominated by ∼20 kcal/mol. Coarse-grained molecular dynamics simulations suggest that the observed enthalpic enhancement results from structurally confining the DNA on the nanoparticle surface and preventing it from adopting enthalpically unfavorable conformations like those observed in the solution case. The idea that structural confinement leads to the formation of energetically more stable duplexes is evaluated by decreasing the degree of confinement a duplex experiences on the nanoparticle surface. Both experiment and simulation confirm that when the surface-bound duplex is less confined, i.e., at lower DNA surface density or at greater distance from the nanoparticle surface, its enthalpy of formation approaches the less favorable enthalpy of duplex formation for the linear strand in solution. This work provides insight into one of the most important and enabling properties of SNAs and will inform the design of materials that rely on the thermodynamics of hybridization onto DNA-functionalized surfaces, including diagnostic probes and therapeutic agents.
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