Evidence map›Paper›PMID 29761654›Full record

ArticleJournal of cachexia, sarcopenia and muscle2018

Low-load resistance exercise during inactivity is associated with greater fibre area and satellite cell expression in older skeletal muscle.

Daniel R Moore, Ryan P Kelly, Michaela C Devries, Tyler A Churchward-Venne, Stuart M Phillips, Gianni Parise, Adam P Johnston

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
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  7. Article
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  12. Physiology of sedentary behavior.Physiological reviews · 2023
    Review
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  18. Muscle Wasting and Sarcopenia in Heart Failure-The Current State of Science.International journal of molecular sciences · 2020
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Daniel R MooreFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Ryan P KellyDepartment of Applied Human Sciences, University of Prince Edward Island, Charlottetown, PE, Canada.
Michaela C DevriesDepartment of Kinesiology, University of Waterloo, Waterloo, ON, Canada.
Tyler A Churchward-VenneDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.
Stuart M PhillipsDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.
Gianni PariseDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.
Adam P JohnstonDepartment of Applied Human Sciences, University of Prince Edward Island, Charlottetown, PE, Canada.
McMaster University · CAUniversity of Prince Edward Island · CAUniversity of Toronto · CAUniversity of Waterloo · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAge-related sarcopenia is accelerated by physical inactivity. Low-load resistance exercise (LLRE) counters inactivity-induced muscle atrophy in older adults, but changes in muscle fibre morphology are unstudied. We aimed to determine the impact of LLRE during short-term inactivity (step-reduction) on muscle fibre size and capillarity as well as satellite cell (SC) content in older skeletal muscle.

methodsFourteen older (~71 years) male adults underwent 14 days of step reduction (<1500 steps/day) while performing six sessions of LLRE (~30% maximal strength) with one leg (SR + EX) while the contralateral leg served as an untrained control (SR). Seven healthy ambulatory age-matched male adults (~69 years) served as a comparator group (COM). Muscle biopsies were taken from the vastus lateralis after 14 days, and immunohistochemical analysis was performed to determine muscle fibre cross-sectional area (CSA), myonuclear content, SC content (PAX7

resultsType I and II fibre CSA was greater in SR + EX compared with SR. Whereas there were no differences across fibre types between SR + EX and CON, type II fibre CSA was significantly lower in SR compared with COM. Type II myonuclear domain was greater in SR + EX compared with COM and SR. Pax7

conclusionsMinimal LLRE during a period of decreased physical activity is associated with greater muscle fibre CSA, SC content, and capillarization. These results support the use of LLRE as an effective countermeasure to inactivity-induced alterations in muscle morphology with age.

Indexed as

Gene ExpressionResistance TrainingAgedBiomarkersBiopsyHumansMaleMuscle Fibers, SkeletalMuscle, SkeletalSatellite Cells, Skeletal MuscleBiomarkersAgeingExerciseInactivityMuscle fibresMuscle stem cellSarcopenia

Identifiers

PMID29761654
PMCPMC6104111
OpenAlexW2804799855

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.