ArticleStem cells (Dayton, Ohio)2018
Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction.
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Article in Stem cells (Dayton, Ohio), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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40citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Retinal manifestations in patients with SARS-CoV-2 infection and pathogenetic implications: a systematic review.International ophthalmology · 2022Pooled it
- Hyperglycemia-Induced Endothelial Dysfunction: From Classical Pathogenetic Mechanisms to Emerging Insights into ACE2 Protective Action.International journal of molecular sciences · 2026Review
- Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Systems biology and microbiome innovations for personalized diabetic retinopathy management.NPJ systems biology and applications · 2025Review
- Alamandine inhibits pathological retinal neovascularization by targeting the MrgD-mediated HIF-1α/VEGF pathway.Journal of Zhejiang University. Science. B · 2025Article
- Branch retinal artery occlusion in a patient with COVID-19 infection: A case report.The Journal of international medical research · 2024Article
- The spike of acute angle closure after the epidemic downgrade of COVID-19 management: a hospital-based comparative study from China.International ophthalmology · 2024Article
- Bibliometric and visual analysis of ACE2/Ang 1-7/MasR axis in diabetes and its microvascular complications from 2000 to 2023.Heliyon · 2024Article
- NOD1 deficiency ameliorates the progression of diabetic retinopathy by modulating bone marrow-retina crosstalk.Stem cell research & therapy · 2024Article
- Diabetic retinopathy: emerging concepts of current and potential therapy.Naunyn-Schmiedeberg's archives of pharmacology · 2023Review
- Targeting the Gut-Eye Axis: An Emerging Strategy to Face Ocular Diseases.International journal of molecular sciences · 2023Review
- Sustained ACE2 Expression by Probiotic Improves Integrity of Intestinal Lymphatics and Retinopathy in Type 1 Diabetic Model.Journal of clinical medicine · 2023Article
- Long COVID: Clinical Framing, Biomarkers, and Therapeutic Approaches.Journal of personalized medicine · 2023Review
- Maintenance of Enteral ACE2 Prevents Diabetic Retinopathy in Type 1 Diabetes.Circulation research · 2023Article
- Proteomic analysis of low- and high-grade human colon adenocarcinoma tissues and tissue-derived primary cell lines reveals unique biological functions of tumours and new protein biomarker candidates.Clinical proteomics · 2022Article
- Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?International journal of molecular sciences · 2022Article
- Dapagliflozin protects neural and vascular dysfunction of the retina in diabetes.BMJ open diabetes research & care · 2022Article
- Lipids, hyperreflective crystalline deposits and diabetic retinopathy: potential systemic and retinal-specific effect of lipid-lowering therapies.Diabetologia · 2022Review
- Angiotensin-converting enzyme 2 inhibits inflammation and apoptosis in high glucose-stimulated microvascular endothelial cell damage by regulating the JAK2/STAT3 signaling pathway.Bioengineered · 2022Article
- Blood protein profiles related to preterm birth and retinopathy of prematurity.Pediatric research · 2022Article
Corrections and comments
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Authors and funding
21 authors at 8 institutions in 3 countries.
Yaqian DuanDepartment of Cellular and Integrative Physiology, Jacksonville, Florida, USA.ORCID 0000-0003-2931-7864
Eleni BeliDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Jacksonville, Florida, USA.
Sergio Li CalziDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Jacksonville, Florida, USA.
Judith L QuigleyDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Jacksonville, Florida, USA.
Rehae C MillerDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Jacksonville, Florida, USA.
Leni MoldovanDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Jacksonville, Florida, USA.
Dongni FengDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Jacksonville, Florida, USA.
Tatiana E SalazarDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Jacksonville, Florida, USA.
Sugata HazraDepartment of Biological Sciences and Bioengineering, IIT Kanpur, Kanpur, India.
Jude Al-SabahDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Jacksonville, Florida, USA.
Kakarla V ChalamDepartment of Ophthalmology, University of Florida, Jacksonville, Florida, USA.
Thao Le Phuong TrinhDepartment of Cellular and Integrative Physiology, Jacksonville, Florida, USA.
Marya MerouehDepartment of Cellular and Integrative Physiology, Jacksonville, Florida, USA.
Troy A MarkelRiley Hospital for Children, Pediatric Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Matthew C MurraySpace Life Sciences Research Branch, NASA Ames Research Center, Moffett Field, California, USA.
Ruchi J VyasCarl Zeiss Meditec, Inc., Dublin, California, USA.
Michael E BoultonDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Jacksonville, Florida, USA.
Patricia Parsons-WingerterSpace Life Sciences Research Branch, NASA Ames Research Center, Moffett Field, California, USA.
Gavin Y OuditDepartment of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.
Alexander G ObukhovDepartment of Cellular and Integrative Physiology, Jacksonville, Florida, USA.
Maria B GrantDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Jacksonville, Florida, USA.
Florida College of Integrative Medicine · USUniversity of Alabama at Birmingham · USAmes Research Center · USCarl Zeiss (United States) · USIndian Institute of Technology Kanpur · INRiley Hospital for Children · USUniversity of Alberta · CAUniversity of Florida · US
Funding
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5MTranslation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4MNITRIC OXIDE IN THE PATHOGENESIS OF DIABETIC RETINOPATHYR01EY012601 · NEI · UNIVERSITY OF FLORIDA · PI Julia V Busik, Maria Bartolomeo Grant · 1998 to 2026
$9.6MTargeting the IGF-1 System in Retinal AngiogenesisR01EY007739 · NEI · UNIVERSITY OF FLORIDA · PI ABCOUWER, STEVEN F, GRANT, MARIA BARTOLOMEO · 1995 to 2015
$5.4MTRPC Channels in the Metabolic SyndromeR01HL115140 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI OBUKHOV, ALEXANDER G. · 2012 to 2016
$2.6MVascular Reparative Mechanism by ACE2/Ang-(1-7)in DiabetesR01HL110170 · NHLBI · UNIVERSITY OF FLORIDA · PI GRANT, MARIA BARTOLOMEO · 2011 to 2015
$2.2MSomatostatin blockade of CNS autonomic hyperactivity for treatment of diabetic retinopathyR01EY028037 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOULTON, MICHAEL EDWIN, FRAZIER, CHARLES J · 2017 to 2020
$1.9MACE2 Modulates the Bone Marrow- Gut Axis in Diabetic RetinopathyR01EY028858 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOULTON, MICHAEL EDWIN, GRANT, MARIA BARTOLOMEO · 2018 to 2021
$1.6MNEI NIH HHS R01 EY007739NEI NIH HHS R01 EY012601NEI NIH HHS R01 EY028037NEI NIH HHS R01 EY028858NHLBI NIH HHS R01 HL110170NHLBI NIH HHS R01 HL115140NIDDK NIH HHS P30 DK079626NIDDK NIH HHS P30 DK097512
Abstract
Angiotensin-converting enzyme 2 (ACE2) is the primary enzyme of the vasoprotective axis of the renin angiotensin system (RAS). We tested the hypothesis that loss of ACE2 would exacerbate diabetic retinopathy by promoting bone marrow dysfunction. ACE2
Indexed as
Angiotensin-Converting Enzyme 2AnimalsBone MarrowDiabetic RetinopathyDisease Models, AnimalHumansMicePeptidyl-Dipeptidase AACE2 protein, humanAce2 protein, mouseAngiotensin-Converting Enzyme 2Peptidyl-Dipeptidase ABone marrowCD34+DiabetesHematopoietic progenitorsRetina
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.