ArticleInternational journal of geriatric psychiatry2018
Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes.
Article in International journal of geriatric psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Deep brain stimulation of the fornix for Alzheimer's disease: A systematic review and meta-analysis of cognitive outcomes.Neurosurgical review · 2026Pooled it
- The Italian guideline on diagnosis and treatment of dementia and mild cognitive impairment.Age and ageing · 2024Guideline
- Coevolution of Cognitive and Health Trajectories Among US Older Adults With Cognitive Impairment.Journal of the American Medical Directors Association · 2026Article
- Neuropsychiatric symptoms and gait/balance are predictors of functional trajectories in dementias.Dementia & neuropsychologia · 2026Article
- The two faces of elderspeak.NPJ dementia · 2026Review
- Latent classes and progression of Mini-Mental State Examination scores in young-onset dementia: Data from the Swedish Dementia Register.Journal of Alzheimer's disease : JAD · 2025Article
- Care Recipients' Cognitive Trajectories and Caregivers' Depressive Symptoms: The Mediating Role of Caregiving Burden.The Gerontologist · 2025Article
- Fast Declining Prediction in Alzheimer's Disease from Early Clinical Assessment.Current neuropharmacology · 2025Observational
- Validity of the Tablet-Based Digital Cognitive Test (SCST) in Identifying Different Degrees of Cognitive Impairment.Journal of Korean medical science · 2024Article
- Proteomic clusters underlie heterogeneity in preclinical Alzheimer's disease progression.Brain : a journal of neurology · 2023Article
- Association of marital status with cognitive function in Chinese hypertensive patients: a cross-sectional study.BMC psychiatry · 2022Article
- Incident Care Trajectories for Older Adults With and Without Dementia.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- Model-based stratification of progression along the Alzheimer disease continuum highlights the centrality of biomarker synergies.Alzheimer's research & therapy · 2022Article
- Is Amyloid Burden Measured by 18F-Flutemetamol PET Associated with Progression in Clinical Alzheimer's Disease?Journal of Alzheimer's disease : JAD · 2022Observational
- Article
- Classification, Prediction, and Concordance of Cognitive and Functional Progression in Patients with Mild Cognitive Impairment in the United States: A Latent Class Analysis.Journal of Alzheimer's disease : JAD · 2021Article
- Shifting Tides Toward a Proactive Patient-Centered Approach in Dysphagia Management of Neurodegenerative Disease.American journal of speech-language pathology · 2020Article
- Prescribing medications of questionable benefit prior to death: a retrospective study on older nursing home residents with and without dementia in Germany.European journal of clinical pharmacology · 2020Article
- Cognitive and functional progression of dementia in two longitudinal studies.International journal of geriatric psychiatry · 2019Article
- Understanding and predicting the longitudinal course of dementia.Current opinion in psychiatry · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveWe sought to replicate a previously published prediction model for progression, developed in the Cache County Dementia Progression Study, using a clinical cohort from the National Alzheimer's Coordinating Center.
methodsWe included 1120 incident Alzheimer disease (AD) cases with at least one assessment after diagnosis, originating from 31 AD centres from the United States. Trajectories of the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating sum of boxes (CDR-sb) were modelled jointly over time using parallel-process growth mixture models in order to identify latent classes of trajectories. Bias-corrected multinomial logistic regression was used to identify baseline predictors of class membership and compare these with the predictors found in the Cache County Dementia Progression Study.
resultsThe best-fitting model contained 3 classes: Class 1 was the largest (63%) and showed the slowest progression on both MMSE and CDR-sb; classes 2 (22%) and 3 (15%) showed moderate and rapid worsening, respectively. Significant predictors of membership in classes 2 and 3, relative to class 1, were worse baseline MMSE and CDR-sb, higher education, and lack of hypertension. Combining all previously mentioned predictors yielded areas under the receiver operating characteristic curve of 0.70 and 0.75 for classes 2 and 3, respectively, relative to class 1.
conclusionsOur replication study confirmed that it is possible to predict trajectories of progression in AD with relatively good accuracy. The class distribution was comparable with that of the original study, with most individuals being members of a class with stable or slow progression. This is important for informing newly diagnosed AD patients and their caregivers.
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