Evidence map›Paper›PMID 29761468›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2018

Using FlyBase to Find Functionally Related Drosophila Genes.

Alix J Rey, Helen Attrill, Steven J Marygold, FlyBase Consortium

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Using FlyBase: A Database of Drosophila Genes and Genetics.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  4. Article
  5. Matrix biology plus · 2019
    Article
  6. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase.Database : the journal of biological databases and curation · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alix J ReyDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. alix.j.rey@gmail.com.
Helen AttrillDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Steven J MarygoldDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
FlyBase Consortium
University of Cambridge · GB

Funding

FLYBASE: A DROSOPHILA RELATIONAL DATABASEP41HG000739 · NHGRI · HARVARD UNIVERSITY · PI GELBART, WILLIAM MARTIN · 1992 to 2014
$56.6M
Resource ProjectU41HG002273 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHERRY, J. MICHAEL, MUNGALL, CHRISTOPHER J · 2012 to 2021
$34.7M
Resource Project CoreU41HG000739 · NHGRI · HARVARD UNIVERSITY · PI PERRIMON, NORBERT · 2014 to 2022
$32.3M
Medical Research Council MR/N030117/1NHGRI NIH HHS P41 HG000739NHGRI NIH HHS U41 HG000739NHGRI NIH HHS U41 HG002273
6 · The paper itself

Abstract

For more than 25 years, FlyBase ( flybase.org ) has served as an online database of biological information on the genus Drosophila, concentrating on the model organism D. melanogaster. Traditionally, FlyBase data have been organized and presented at a gene-by-gene level, which remains a useful perspective when the object of interest is a specific gene or gene product. However, in the modern era of a fully sequenced genome and an increasingly characterized proteome, it is often desirable to compile and analyze lists of genes related by a common function. This may be achieved in FlyBase by searching for genes annotated with relevant Gene Ontology (GO) terms and/or protein domain data. In addition, FlyBase provides preassembled lists of functionally related D. melanogaster genes within "Gene Group" reports. These are compiled manually from the published literature or expert databases and greatly facilitate access to, and analysis of, established gene sets. This chapter describes protocols to produce lists of functionally related genes in FlyBase using GO annotations, protein domain data and the Gene Groups resource, and provides guidance and advice for their further analysis and processing.

Indexed as

Databases, GeneticGenes, InsectGenome, InsectGenomicsAnimalsDrosophilaGene OntologyInformaticsSearch EngineSoftwareUser-Computer InterfaceWeb BrowserDatabaseD. melanogasterDrosophilaFlyBaseFunctionally related genesGene groupGene OntologyProtein domain

Identifiers

PMID29761468
PMCPMC5996772
OpenAlexW2803630151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.