ArticleEuropean journal of epidemiology2018
Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium.
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Article in European journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
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38citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 4% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Parental Age and Childhood Lymphoma and Solid Tumor Risk: A Literature Review and Meta-Analysis.JNCI cancer spectrum · 2022Pooled it
- Maternal Body Mass Index, Diabetes, and Gestational Weight Gain and Risk for Pediatric Cancer in Offspring: A Systematic Review and Meta-Analysis.JNCI cancer spectrum · 2022Pooled it
- Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring: findings from the Childhood Leukaemia International Consortium (CLIC).Occupational and environmental medicine · 2019Pooled it
- The Childhood Cancer and Leukemia International Consortium (CLIC): Expanding global collaboration in pediatric cancer etiology research.Cancer epidemiology · 2026Review
- Article
- Incidence patterns and temporal trends of childhood cancer in Germany, 1980-2019: Forty years of childhood cancer registration in Germany.International journal of cancer · 2026Article
- Exploring the knowledge, attitudes, and perceptions of young men towards fertility in the UK: A cross-sectional survey.PloS one · 2026Article
- Ambient Fine Particulate Matter, Residential Greenness, and Childhood Cancer Risk by Trimester of Exposure in Minnesota 2000 to 2014: A Case-Control Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Causes of Childhood Cancer: A Review of Literature (2014-2021): Part 2-Pregnancy and Birth-Related Factors.Cancers · 2025Review
- Prenatal and Perinatal Factors Associated with Infant Acute Lymphoblastic Leukaemia: A Scoping Review.Cancers · 2025Review
- Investigating the Impact of LNA-anti-miR-92b, miR-181b, TNF-α, and Piperine on Gene Expression and Cell Viability in Jurkat Cells: Implications for Acute Lymphoblastic Leukemia : LNA-anti- MicroRNAs and Jurkat Cells.Galen medical journal · 2025Article
- Impact of standardized immunophenotyping and MRD monitoring on early mortality reduction in childhood leukemia: a step towards addressing healthcare disparities in vulnerable populations from Southern Mexico.Frontiers in oncology · 2025Article
- In Utero Origins of Acute Leukemia in Children.Biomedicines · 2024Review
- Racial and ethnic and socioeconomic disparities in childhood cancer incidence trends in the United States, 2000-2019.Journal of the National Cancer Institute · 2023Article
- Incidence and Mortality Rates for Childhood Acute Lymphoblastic Leukemia in Puerto Rican Hispanics, 2012-2016.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Outdoor artificial light at night, air pollution, and risk of childhood acute lymphoblastic leukemia in the California Linkage Study of Early-Onset Cancers.Scientific reports · 2023Article
- Maternal diet in pregnancy and acute leukemia in infants: a case-control study in Mexico City.Frontiers in oncology · 2023Article
- Environmental Risk Factors for Pediatric Acute Leukemia: Methodology and Early Findings.International journal of preventive medicine · 2023Article
- Pediatric Cancer By Race, Ethnicity and Region in the United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Infant feeding practices and childhood acute leukemia: Findings from the Childhood Cancer & Leukemia International Consortium.International journal of cancer · 2022Article
Corrections and comments
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Authors and funding
26 authors at 20 institutions in 13 countries.
Eleni Th PetridouDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str, 11527, Athens, Greece. epetrid@med.uoa.gr.
Marios K GeorgakisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str, 11527, Athens, Greece.
Friederike ErdmannSection of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.
Xiaomei MaDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Cancer Prevention and Control, Yale Comprehensive Cancer Center, Yale School of Medicine, New Haven, CT, USA.
Julia E HeckDepartment of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
Anssi AuvinenFaculty of Social Sciences, University of Tampere, Tampere, Finland.
Beth A MuellerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Logan G SpectorDivision of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Eve RomanEpidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, Heslington, York, UK.
Catherine MetayerSchool of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Corrado MagnaniDipartimento di Medicina Traslazionale, SCDU Epidemiologia del Tumori, Universitá del Piemonte Orientale, Novara, Italy.
Maria S Pombo-de-OliveiraPediatric Hematology-Oncology Program, Instituto Nacional de Cancer, Rio de Janeiro, Brazil.
Sameera EzzatDepartment of Epidemiology and Preventive Medicine, NLI-SSI Collaborative Research Center, National Liver Institute, Menoufia University, Cairo, Egypt.
Michael E ScheurerDepartment of Pediatrics Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Ana Maria MoraCentral American Institute for Studies on Toxic Substances (IRET), Universidad Nacional, Heredia, Costa Rica.
John D DockertyDepartment of Preventative and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Johnni HansenDanish Cancer Society Research Center, Copenhagen, Denmark.
Alice Y KangSchool of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Rong WangDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Cancer Prevention and Control, Yale Comprehensive Cancer Center, Yale School of Medicine, New Haven, CT, USA.
David R DoodyPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Eleanor KaneEpidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, Heslington, York, UK.
Waffa M RashedResearch Department, Children's Cancer Hospital Egypt, Cairo, Egypt.
Nick DessyprisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str, 11527, Athens, Greece.
Joachim SchüzSection of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.
Claire Infante-RivardDepartment of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Alkistis SkalkidouDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
National and Kapodistrian University of Athens · GRDanish Cancer Society · DKFred Hutch Cancer Center · USUniversity of York · GBYale Cancer Center · USArmed Forces College of Medicine · EGBerkeley Public Health Division · USCentre International de Recherche sur le Cancer · FRChildren's Cancer Center · USInstituto Nacional do Câncer · BRMcGill University · CAMenoufia University · EGTampere University · FIUniversidad Nacional · CRUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of California, Berkeley · USUniversity of California, Los Angeles · USUniversity of Minnesota · USUniversity of Otago · NZUppsala University · SE
Funding
Environmental and Molecular Epidemiology of Childhood LeukemiaR01ES009137 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 1999 to 2013
$21.1MMinnesota Population Center Science and Technical CoreP2CHD041023 · NICHD · UNIVERSITY OF MINNESOTA · PI THERESA LOUISE OSYPUK · 2016 to 2026
$4.3MGenome-Wide Association Study of Childhood Leukemia by Hispanic StatusR01CA155461 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, XIAOMEI, WIEMELS, JOSEPH LEO · 2011 to 2014
$4.1MProject 3: Prenatal Exposure, DNA Methylation & Childhood LeukemiaP01ES018172 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2009 to 2013
$3.7MSupport For Infrastructure of Childhood Leukemia Environmental ResearchR24ES028524 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Robert Gunier · 2017 to 2026
$2.3MMaternal comorbidities, prescription drug use in pregnancy and childhood cancerR21CA175959 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2014 to 2015
$323kParental Occupation and Childhood CancersR03ES021643 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2012 to 2013
$152kChildhood Leukemia International Consortium (CLIC)R03CA132172 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI BUFFLER, PATRICIA A · 2007 to 2008
$125kChildhood Leukemia International Consortium Scientific Annual MeetingsU13ES026496 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2015 to 2018
$51k2012 Annual Scientific Meeting of the International Childhood Leukemia ConsortiumR13ES022868 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2012 to 2012
$18k2014 Childhood Leukemia International Consortium Annual Scientific MeetingR13ES024632 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2014 to 2014
$10k2011 Annual Scientific Meeting of the International Childhood Leukemia ConsortiumR13ES021145 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BUFFLER, PATRICIA A · 2011 to 2011
$10kNCI NIH HHS R01 CA155461NCI NIH HHS R03 CA132172NICHD NIH HHS P2C HD041023NIEHS NIH HHS P01 ES018172NIEHS NIH HHS R01 ES009137NIEHS NIH HHS R13 ES021145NIEHS NIH HHS R13 ES022868NIEHS NIH HHS R13 ES024632NIEHS NIH HHS R24 ES028524NIEHS NIH HHS U13 ES026496World Health Organization 001
Abstract
Advanced parental age has been associated with adverse health effects in the offspring including childhood (0-14 years) acute lymphoblastic leukemia (ALL), as reported in our meta-analysis of published studies. We aimed to further explore the association using primary data from 16 studies participating in the Childhood Leukemia International Consortium. Data were contributed by 11 case-control (CC) studies (7919 cases and 12,942 controls recruited via interviews) and five nested case-control (NCC) studies (8801 cases and 29,690 controls identified through record linkage of population-based health registries) with variable enrollment periods (1968-2015). Five-year paternal and maternal age increments were introduced in two meta-analyses by study design using adjusted odds ratios (OR) derived from each study. Increased paternal age was associated with greater ALL risk in the offspring (OR
Indexed as
Maternal AgePaternal AgePrenatal Exposure Delayed EffectsCase-Control StudiesChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleParentsPrecursor Cell Lymphoblastic Leukemia-LymphomaPregnancyRisk FactorsAcute lymphoblastic leukemiaCase–controlChildhoodMaternal agePaternal ageRisk factors
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