Evidence map›Paper›PMID 29761414›Full record

ArticleMagma (New York, N.Y.)2018

Spatially resolved kinetics of skeletal muscle exercise response and recovery with multiple echo diffusion tensor imaging (MEDITI): a feasibility study.

E E Sigmund, S H Baete, K Patel, D Wang, D Stoffel, R Otazo, P Parasoglou, J Bencardino

Abstract read
In one paragraph

Article in Magma (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

E E SigmundDepartment of Radiology, New York University Langone Health, New York, NY, USA. eric.sigmund@nyumc.org.
S H BaeteDepartment of Radiology, New York University Langone Health, New York, NY, USA.
K PatelDepartment of Radiology, New York University Langone Health, New York, NY, USA.
D WangDepartment of Radiology, New York University Langone Health, New York, NY, USA.
D StoffelDepartment of Radiology, New York University Langone Health, New York, NY, USA.
R OtazoDepartment of Radiology, New York University Langone Health, New York, NY, USA.
P ParasoglouDepartment of Radiology, New York University Langone Health, New York, NY, USA.
J BencardinoDepartment of Radiology, New York University Langone Health, New York, NY, USA.
NYU Langone Health · USAdvanced Imaging Research (United States) · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Dynamical DTI: A Method for Time-Resolved in vivo Diffusion Tensor ImagingR21EB009435 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SIGMUND, ERIC EDWARD · 2010 to 2013
$558k
MRI-compatible Ergometer for Real-Time Quantitative Imaging with Physical ExertionS10OD021702 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SIGMUND, ERIC EDWARD · 2016 to 2016
$100k
NCI NIH HHS P30 CA008748NIBIB NIH HHS R21 EB009435NIBIB NIH HHS R21EB009435NIH HHS S10 OD021702NIH Office of the Director S10OD021702
6 · The paper itself

Abstract

objectivesWe describe measurement of skeletal muscle kinetics with multiple echo diffusion tensor imaging (MEDITI). This approach allows characterization of the microstructural dynamics in healthy and pathologic muscle. MATERIALS AND

methodsIn a Siemens 3-T Skyra scanner, MEDITI was used to collect dynamic DTI with a combination of rapid diffusion encoding, radial imaging, and compressed sensing reconstruction in a multi-compartment agarose gel rotation phantom and within in vivo calf muscle. An MR-compatible ergometer (Ergospect Trispect) was employed to enable in-scanner plantar flexion exercise. In a HIPAA-compliant study with written informed consent, post-exercise recovery of DTI metrics was quantified in eight volunteers. Exercise response of DTI metrics was compared with that of T2-weighted imaging and characterized by a gamma variate model.

resultsPhantom results show quantification of diffusivities in each compartment over its full dynamic rotation. In vivo calf imaging results indicate larger radial than axial exercise response and recovery in the plantar flexion-challenged gastrocnemius medialis (fractional response: nT2w = 0.385 ± 0.244, nMD = 0.163 ± 0.130, nλ

conclusionWe have demonstrated the feasibility of MEDITI for capturing spatially resolved diffusion tensor data in dynamic systems including post-exercise skeletal muscle recovery following in-scanner plantar flexion.

Indexed as

AnisotropyBiomechanical PhenomenaDiffusion Tensor ImagingExerciseFeasibility StudiesHealthy VolunteersHumansImage Interpretation, Computer-AssistedModels, BiologicalMuscle, SkeletalPhantoms, ImagingCompressed sensingDiffusion tensor imagingDynamic imagingMultiple echo diffusion tensor acquisition technique (MEDITATE)

Identifiers

PMID29761414
PMCPMC6437757
OpenAlexW2804647551

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.