Evidence map›Paper›PMID 29761319›Full record

ArticleEuropean journal of nutrition2019

Gaussian graphical models identified food intake networks and risk of type 2 diabetes, CVD, and cancer in the EPIC-Potsdam study.

Khalid Iqbal, Lukas Schwingshackl, Anna Floegel, Carolina Schwedhelm, Marta Stelmach-Mardas, Clemens Wittenbecher, Cecilia Galbete, Sven Knüppel, Matthias B Schulze, Heiner Boeing

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Khalid IqbalDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. khalid.iqbal@dife.de.ORCID http://orcid.org/0000-0002-3312-4259
Lukas SchwingshacklDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Anna FloegelDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Carolina SchwedhelmDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Marta Stelmach-MardasDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Clemens WittenbecherDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsda-Rehbruecke, Nuthetal, Germany.
Cecilia GalbeteNutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Potsdam, Germany.
Sven KnüppelDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Matthias B SchulzeNutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Potsdam, Germany.
Heiner BoeingDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
German Institute of Human Nutrition · DELeibniz Institute for Prevention Research and Epidemiology - BIPS · DEPoznan University of Medical Sciences · PL

Funding

European Union SOC 95201408 05F02German Federal Ministry of Science 01 EA 9401Higher Education Commission of Pakistan and German Academic Exchange Program, Germany 50015451
6 · The paper itself

Abstract

purposeThe aim of the study was to investigate the association between the previously identified Gaussian graphical models' (GGM) food intake networks and risk of major chronic diseases as well as intermediate biomarkers in the European Prospective Investigation into Cancer and nutrition (EPIC)-Potsdam cohort.

methodsIn this cohort analysis of 10,880 men and 13,340 women, adherence to the previously identified sex-specific GGM networks as well as principal component analysis identified patterns was investigated in relation to risk of major chronic diseases, using Cox-proportional hazard models. Associations of the patterns with intermediate biomarkers were cross-sectionally analyzed using multiple linear regressions.

resultsResults showed that higher adherence to the GGM Western-type pattern was associated with increased risk (Hazard Ratio: 1.55; 95% CI 1.13-2.15; P trend = 0.004) of type 2 diabetes (T2D) in women, whereas adherence to a high-fat dairy (HFD) pattern was associated with lower risk of T2D both in men (0.69; 95% CI 0.54-0.89; P trend < 0.001) and women (0.71; 95% CI: 0.53, 0.96; P trend = 0.09). Among PCA patterns, HFD pattern was associated with lower risk of T2D (0.74; 95% CI 0.58-0.95; P trend < 0.001) in men and bread and sausage pattern was associated with higher risk of T2D (1.79; 95% CI 1.29-2.48; P trend < 0.001) in women. Moreover, The GGM-HFD pattern was positively associated with HDL-C in men and inversely associated with C-reactive protein in women.

conclusionOverall, these results show that GGM-identified networks reflect dietary patterns, which could also be related to risk of chronic diseases.

Indexed as

Models, StatisticalAdultBiomarkersCardiovascular DiseasesCohort StudiesCross-Sectional StudiesDiabetes Mellitus, Type 2DietEuropeFemaleGermanyHumansMaleMiddle AgedNeoplasmsProportional Hazards ModelsBiomarkersChronic diseasesDietary patternsGaussian graphical modelsNetworksType 2 diabetesWestern-type

Identifiers

PMID29761319
OpenAlexW2801134305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.