Evidence map›Paper›PMID 29761244›Full record

ArticleInvestigational new drugs2019

Copper-tolfenamic acid: evaluation of stability and anti-cancer activity.

Myrna Hurtado, Umesh T Sankpal, Jaya Chhabra, Deondra T Brown, Rajasekhar Maram, Rafid Patel, Raj K Gurung, Jerry Simecka, Alvin A Holder, Riyaz Basha

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Investigational new drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Crystal Structure and Chemical Bonds in [CuInternational journal of molecular sciences · 2023
    Article
  7. Article
  8. Article
  9. Novel Survivin Inhibitor for Suppressing Pancreatic Cancer Cells Growth via Downregulating Sp1 and Sp3 Transcription Factors.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Myrna HurtadoGraduate School of Biomedical Sciences, Fort Worth, TX, USA.
Umesh T SankpalTexas College of Osteopathic Medicine, UNT Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107, USA.
Jaya ChhabraDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, VA, 23529, USA.
Deondra T BrownDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, VA, 23529, USA.
Rajasekhar MaramTexas College of Osteopathic Medicine, UNT Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107, USA.
Rafid PatelTexas College of Osteopathic Medicine, UNT Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107, USA.
Raj K GurungDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, VA, 23529, USA.
Jerry SimeckaPre-clinical Services, UNT Systems College of Pharmacy, UNT Health Science Center, Fort Worth, TX, 76107, USA.
Alvin A HolderDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, VA, 23529, USA.
Riyaz BashaGraduate School of Biomedical Sciences, Fort Worth, TX, USA. Riyaz.Basha@unthsc.edu.
Old Dominion University · USUniversity of North Texas · USUniversity of North Texas Health Science Center · USFort Worth Library · USTexas College · US

Funding

AIM-AHEAD Coordinating Center - All Four CoresOT2OD032581 · OD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Paul Avillach, Bettina M. Beech · 2021 to 2026
$168.7M
Texas Minority Health, Research and Outreach (MiHERO)S21MD012472 · NIMHD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JAMBOOR K. VISHWANATHA · 2017 to 2026
$18.0M
Texas Center for Minority Health, Education, Research and OutreachU54MD006882 · NIMHD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI VISHWANATHA, JAMBOOR K. · 2017 to 2022
$6.0M
Triple Negative Breast Cancer: Novel Biomarkers and Therapeutic StrategiesP20MD006882 · NIMHD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI VISHWANATHA, JAMBOOR K. · 2012 to 2016
$5.8M
2/2 Pilot Project 2: Langston University-UNTHSC Partnership for Cancer Research and EducationP20CA233391 · NCI · LANGSTON UNIVERSITY · PI HUNTER, TERESSA · 2018 to 2021
$777k
NCI NIH HHS P20 CA233391NIH HHS OT2 OD032581NIMHD NIH HHS P20 MD006882NIMHD NIH HHS S21 MD012472NIMHD NIH HHS U54 MD006882
6 · The paper itself

Abstract

The non-steroidal anti-inflammatory drug, Tolfenamic acid (TA) acts as an anti-cancer agent in several adult and pediatric cancer models. Copper (Cu) is an important element with multiple biological functions and has gained interest in medical applications. Recently, [Cu(TA)

Indexed as

Anti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsApoptosisCell ProliferationCopperHumansNeoplasmsortho-AminobenzoatesTumor Cells, CulturedAnti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsCopperortho-Aminobenzoatestolfenamic acidCardiomyocytesCopper-Tolfenamic acidSpecificity protein 1Survivin

Identifiers

PMID29761244
PMCPMC6237668
OpenAlexW2805000505

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.