ReviewEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2018
Polymorphous adenocarcinoma of the salivary glands: reappraisal and update.
Review in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Guideline
- Integrative diagnostic approach to salivary gland tumors: from clinical evaluation to molecularly targeted therapy.Virchows Archiv : an international journal of pathology · 2025Review
- Atypical and worrisome histological features in pleomorphic adenoma: challenging and potentially significant diagnostic pitfall.Virchows Archiv : an international journal of pathology · 2025Article
- Polymorphous adenocarcinoma: a review of the literature and presentation of a case in an uncommon anatomical area.Medicine and pharmacy reports · 2025Article
- Polymorphous adenocarcinoma-like tumor of the breast: the first case report from Japan.Breast cancer (Tokyo, Japan) · 2025Article
- Polymorphous Adenocarcinoma of the Parotid Gland: A Rare Entity in Asians With a Unique Cystic Presentation.Clinical case reports · 2025Article
- NanoString nCounter-Based Assay for Detection of Fusion-Associated Salivary Gland Tumors.Head and neck pathology · 2024Article
- Review
- An unusual neck mass diagnosed by fine needle aspiration: Cytological findings and challenges.CytoJournal · 2024Article
- Minor Salivary Gland Polymorphous Adenocarcinoma With Local Recurrence After Seven Years: A Case Report.Cureus · 2023Article
- Stereotactic radiosurgery for recurrent skull base polymorphous adenocarcinoma invading the cavernous sinus: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Cribriform adenocarcinoma of the minor salivary glands: a case report.Journal of medical case reports · 2023Article
- Minor Salivary Gland Cancer of the Head and Neck: A Review of Epidemiologic Aspects, Prognostic Factors, and Outcomes.Current oncology reports · 2023Review
- High-grade transformation of a polymorphous adenocarcinoma of the salivary gland: a case report and review of the literature.Frontiers in oncology · 2023Article
- Polymorphous Adenocarcinoma: High-Grade Transformation With Immunohistochemical Workup.Cureus · 2022Article
- Salivary gland cancers in elderly patients: challenges and therapeutic strategies.Frontiers in oncology · 2022Review
- Primary Pituitary Adenoid Cystic Carcinoma: A Rare Salivary Gland-Like Tumor in the Sella.Head and neck pathology · 2021Article
- Canalicular adenoma: palatal presentation of an uncommon lesion.BMJ case reports · 2021Article
- Role of elective neck dissection and adjuvant radiation therapy in patients with polymorphous adenocarcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- SalvGlandDx - a comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets.Neoplasia (New York, N.Y.) · 2021Article
Corrections and comments
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Authors and funding
16 authors at 14 institutions in 13 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.