ArticleAnnals of clinical and translational neurology2018
Antibodies against cell adhesion molecules and neural structures in paraneoplastic neuropathies.
Article in Annals of clinical and translational neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Pathologic and Therapeutic Schwann Cells.Cells · 2025Review
- Anti-contactin-1 autoimmune nodopathy with thymoma: case report and literature review.Frontiers in immunology · 2025Review
- Synthetic and semi-synthetic antioxidants in medicine and food industry: a review.Frontiers in pharmacology · 2025Review
- Paraneoplastic Syndrome Presenting Combined Central and Peripheral Demyelination Associated with Anti-CV2/CRMP5 and Anti-NF186 Antibodies: A Case Report.Brain sciences · 2023Article
- Guillain-Barré Syndrome Following Zika Virus Infection Is Associated With a Diverse Spectrum of Peripheral Nerve Reactive Antibodies.Neurology(R) neuroimmunology & neuroinflammation · 2023Article
- Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration.Development (Cambridge, England) · 2022Article
- Autoantibody screening in Guillain-Barré syndrome.Journal of neuroinflammation · 2021Observational
- Acute anti-Ma2 paraneoplastic encephalitis associated to pembrolizumab: a case report and review of literature.Translational lung cancer research · 2021Article
- Upregulation of Neural Cell Adhesion Molecule 1 (NCAM1) by hsa-miR-141-3p Suppresses Ameloblastoma Cell Migration.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- A deceiving case of paraplegia.Internal and emergency medicine · 2020Article
- The Role of Contactin 1 in Cancers: What We Know So Far.Frontiers in oncology · 2020Review
- Diagnostic insights into chronic-inflammatory demyelinating polyneuropathies.Annals of translational medicine · 2018Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveParaneoplastic neurological syndromes (PNS) are rare neurological disorders in which ectopic expression of neural antigens by a tumor results in an autoimmune attack against the nervous system. Onconeural antibodies not only guide PNS diagnosis but may also help detecting underlying malignancies. Our project aims to uncover new potential antibodies in paraneoplastic neuropathies (PN).
methodsThirty-four patients fulfilling diagnostic criteria of possible (
resultsOverall, 9 (26.5%) patients showed significant reactivity against DRG neurons, motor neurons, or Schwann cells, whereas 5 (17.9%) healthy controls only showed moderate reactivity. Compared with control sera, serum samples from patients with paraneoplastic sensory-motor neuropathies had a higher frequency of IgM antibodies against Schwann cells (0% vs. 40%;
interpretationAlmost 30% of patients with PN harbor antibodies targeting neural structures, suggesting that novel neoplasm-associated antigens remain to be discovered.
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Registered trials
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