ReviewJournal of bone and joint infection2018
Current therapies in treatment and prevention of fracture wound biofilms: why a multifaceted approach is essential for resolving persistent infections.
Review in Journal of bone and joint infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Translational Advances in Chitosan Biomaterials: From Molecular Modification to Clinical Medicine.ACS omega · 2026Review
- Chronic osteomyelitis after cephalomedullary nailing for intertrochanteric fractures of the femur: carbon fiber rod bone cement combined with calcium sulfate loaded with antibiotics.Journal of orthopaedic surgery and research · 2025Article
- Clinical features of chronic tibial osteomyelitis: a single-center retrospective study of 282 cases in Xinjiang, China.BMC musculoskeletal disorders · 2024Article
- Osteosynthesis-associated infection in maxillofacial surgery by bacterial biofilms: a retrospective cohort study of 11 years.Clinical oral investigations · 2023Article
- Chitosan Sponges Are Associated With Higher Rates of Wound Complications Compared to Calcium Sulfate Beads.Cureus · 2023Article
- Analyzing risk factors for treatment failure in fracture-related infection.Archives of orthopaedic and trauma surgery · 2023Article
- [Application of homemade antibiotic bone cement rod in tibial screw canal osteomyelitis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023Article
- Anti-biofilm effects and healing promotion by silver oxynitrate-based dressings.Scientific reports · 2023Article
- Definitive fixation in the first stage of the induced membrane technique for septic segmental bone defects. Why not?Journal of clinical orthopaedics and trauma · 2023Article
- Current Concepts of Fracture-Related Infection.International journal of clinical practice · 2023Review
- Recent Progress in antibacterial hydrogel coatings for targeting biofilm to prevent orthopedic implant-associated infections.Frontiers in microbiology · 2023Review
- Bud-Poplar-Extract-Embedded Chitosan Films as Multifunctional Wound Healing Dressing.Molecules (Basel, Switzerland) · 2022Article
- The intersection of fracture healing and infection: Orthopaedics research society workshop 2021.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Review
- Improving the Efficacy of Antimicrobials against Biofilm-Embedded Bacteria Using Bovine Hyaluronidase Azoximer (LongidazaPharmaceutics · 2021Article
- An Enzybiotic Regimen for the Treatment of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect.Scientific reports · 2021Article
- The effectiveness of antibiotic cement-coated nails in post-traumatic femoral and tibial osteomyelitis - comparative analysis of custom-made versus commercially available nails.Journal of bone and joint infection · 2021Article
- Early application of topical antibiotic powder in open-fracture wounds: A strategy to prevent biofilm formation and infections.OTA international : the open access journal of orthopaedic trauma · 2020Article
- Synthesis, Characterization, and Bacterial Fouling-Resistance Properties of Polyethylene Glycol-Grafted Polyurethane Elastomers.International journal of molecular sciences · 2019Article
- Application of Antimicrobial Peptides of the Innate Immune System in Combination With Conventional Antibiotics-A Novel Way to Combat Antibiotic Resistance?Frontiers in cellular and infection microbiology · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic orthopedic injuries, particularly extremity wounds, are a significant cause of morbidity. Despite prophylactic antibiotic treatment and surgical intervention, persistent infectious complications can and do occur. Persistent bacterial infections are often caused by biofilms, communities of antibiotic tolerant bacteria encased within a matrix. The structural and metabolic differences in this mode of growth make treatment difficult. Herein, we describe both established and novel, experimental treatments targeted at various stages of wound healing that are specifically aimed at reducing and eliminating biofilm bacteria. Importantly, the highly tolerant nature of these bacterial communities suggests that most singular approaches could be circumvented and a multifaceted, combinatorial approach will be the most effective strategy for treating these complicated infections.
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