ArticleBrain and behavior2018
The importance of hippocampal dynamic connectivity in explaining memory function in multiple sclerosis.
Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Resting-state functional connectivity and cognitive impairment after COVID-19 infection: Evidence from a large-scale fMRI study.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- White matter integrity of default mode network after a 3-month aerobic dance program in patients with amnestic mild cognitive impairment: a secondary analysis of a randomized clinical trial.Quantitative imaging in medicine and surgery · 2025Article
- Abnormal thalamic functional connectivity correlates with cardiorespiratory fitness and physical activity in progressive multiple sclerosis.Journal of neurology · 2023Article
- Microstates in multiple sclerosis: an electrophysiological signature of altered large-scale networks functioning?Brain communications · 2023Article
- Larger lesion volume in people with multiple sclerosis is associated with increased transition energies between brain states and decreased entropy of brain activity.Network neuroscience (Cambridge, Mass.) · 2023Article
- Male and female are not the same: a multicenter study of static and dynamic functional connectivity in relapse-remitting multiple sclerosis in China.Frontiers in immunology · 2023Article
- Temporal Dynamics of Resting-state Functional Networks and Cognitive Functioning following Systemic Treatment for Breast Cancer.Brain imaging and behavior · 2022Article
- Correlations between hippocampal functional connectivity, structural changes, and clinical data in patients with relapsing-remitting multiple sclerosis: a case-control study using multimodal magnetic resonance imaging.Neural regeneration research · 2022Article
- Functional network dynamics and decreased conscientiousness in multiple sclerosis.Journal of neurology · 2022Article
- Effect of 3-Month Aerobic Dance on Hippocampal Volume and Cognition in Elderly People With Amnestic Mild Cognitive Impairment: A Randomized Controlled Trial.Frontiers in aging neuroscience · 2022Article
- A more unstable resting-state functional network in cognitively declining multiple sclerosis.Brain communications · 2022Article
- The network collapse in multiple sclerosis: An overview of novel concepts to address disease dynamics.NeuroImage. Clinical · 2022Review
- Delayed access to conscious processing in multiple sclerosis: Reduced cortical activation and impaired structural connectivity.Human brain mapping · 2021Article
- Mind the gap: from neurons to networks to outcomes in multiple sclerosis.Nature reviews. Neurology · 2021Review
- Structural and Functional Connectivity Substrates of Cognitive Impairment in Multiple Sclerosis.Frontiers in neurology · 2021Review
- Cognitive Impairment and Brain Reorganization in MS: Underlying Mechanisms and the Role of Neurorehabilitation.Frontiers in neurology · 2020Review
- Characterizing Rapid Fluctuations of Resting State Functional Connectivity in Demyelinating, Neurodegenerative, and Psychiatric Conditions: From Static to Time-Varying Analysis.Frontiers in neuroscience · 2019Review
- Article
- The importance of hippocampal dynamic connectivity in explaining memory function in multiple sclerosis.Brain and behavior · 2018Article
- Dynamic Functional Connectivity and Symptoms of Parkinson's Disease: A Resting-State fMRI Study.Frontiers in aging neuroscience · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Brain dynamics (i.e., variable strength of communication between areas), even at the scale of seconds, are thought to underlie complex human behavior, such as learning and memory. In multiple sclerosis (MS), memory problems occur often and have so far only been related to "stationary" brain measures (e.g., atrophy, lesions, activation and stationary (s) functional connectivity (FC) over an entire functional scanning session). However, dynamics in FC (dFC) between the hippocampus and the (neo)cortex may be another important neurobiological substrate of memory impairment in MS that has not yet been explored. Therefore, we investigated hippocampal dFC during a functional (f) magnetic resonance imaging (MRI) episodic memory task and its relationship with verbal and visuospatial memory performance outside the MR scanner. Methods: Thirty-eight MS patients and 29 healthy controls underwent neuropsychological tests to assess memory function. Imaging (1.5T) was obtained during performance of a memory task. We assessed hippocampal volume, functional activation, and sFC (i.e., FC of the hippocampus with the rest of the brain averaged over the entire scan, using an atlas-based approach). Dynamic FC of the hippocampus was calculated using a sliding window approach. Results: No group differences were found in hippocampal activation, sFC, and dFC. However, stepwise forward regression analyses in patients revealed that lower dFC of the left hippocampus (standardized β = -0.30; Conclusion: Low hippocampal dFC is an important indicator for maintained memory performance in MS, in addition to other hippocampal imaging measures. Hence, brain dynamics may offer new insights into the neurobiological mechanisms underlying memory (dys)function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.