ArticleBiomedical optics express2018
Fiber-based tunable repetition rate source for deep tissue two-photon fluorescence microscopy.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- A versatile platform for two-photon neuronal population voltage imaging across cortical depths.Nature methods · 2026Article
- Two-photon microscopy using picosecond pulses from four-wave mixing in a Yb-doped photonic crystal fiber.Biomedical optics express · 2025Article
- Compact femtosecond fiber laser tunable from 800 to 850 nm with pulse energy exceeding 5 nJ.Scientific reports · 2025Article
- Photophysics-informed two-photon voltage imaging using FRET-opsin voltage indicators.Science advances · 2025Article
- Deep and dynamic metabolic and structural imaging in living tissues.Science advances · 2024Article
- Optimized intravital three-photon imaging of intact mouse tibia links plasma cell motility to functional states.iScience · 2024Article
- Optical constraints on two-photon voltage imaging.Neurophotonics · 2024Article
- Improved image contrast in nonlinear light-sheet fluorescence microscopy using iScientific reports · 2024Article
- Optical constraints on two-photon voltage imaging.bioRxiv : the preprint server for biology · 2024Article
- Photophysics-informed two-photon voltage imaging using FRET-opsin voltage indicators.bioRxiv : the preprint server for biology · 2024Article
- Compact simultaneous label-free autofluorescence multi-harmonic microscopy for user-friendly photodamage-monitored imaging.Journal of biomedical optics · 2024Article
- Numerical study of a convective cooling strategy for increasing safe power levels in two-photon brain imaging.Biomedical optics express · 2024Article
- Pulse train gating to improve signal generation forNeurophotonics · 2023Article
- SNR enhanced high-speed two-photon microscopy using a pulse picker and time gating detection.Scientific reports · 2023Article
- High-speed low-light in vivo two-photon voltage imaging of large neuronal populations.Nature methods · 2023Article
- Pulse train gating to improve signal generation forbioRxiv : the preprint server for biology · 2023Article
- Ultrafast laser surgery probe for sub-surface ablation to enable biomaterial injection in vocal folds.Scientific reports · 2022Article
- Femtosecond Er-doped fiber laser source tunable from 872 to 1075 nm for two-photon vision studies in humans.Biomedical optics express · 2022Article
- Multiphoton excitation imaging via an actively mode-locked tunable fiber-cavity SOA laser around 800 nm.Biomedical optics express · 2022Article
- Imaging deeper than the transport mean free path with multiphoton microscopy.Biomedical optics express · 2022Article
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Authors and funding
5 authors.
Funding
Abstract
Deep tissue multiphoton imaging requires high peak power to enhance signal and low average power to prevent thermal damage. Both goals can be advantageously achieved through laser repetition rate tuning instead of simply adjusting the average power. We show that the ideal repetition rate for deep two-photon imaging in the mouse brain is between 1 and 10 MHz, and we present a fiber-based source with an arbitrarily tunable repetition rate within this range. The performance of the new source is compared to a mode-locked Ti:Sapphire (Ti:S) laser for
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