ArticleBiomedical optics express2018
5-ALA fluorescence and laser Doppler flowmetry for guidance in a stereotactic brain tumor biopsy.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Multimodal fiber probe for simultaneous mid-infrared and Raman spectroscopy.Scientific reports · 2024Article
- Combined Use of Frameless Neuronavigation and In Situ Optical Guidance in Brain Tumor Needle Biopsies.Brain sciences · 2023Article
- Advances, technological innovations, and future prospects in stereotactic brain biopsies.Neurosurgical review · 2022Review
- Diffuse reflectance spectroscopy sensor to differentiate between glial tumor and healthy brain tissue: a proof-of-concept study.Biomedical optics express · 2022Article
- Coronary vessel detection methods for organ-mounted robots.The international journal of medical robotics + computer assisted surgery : MRCAS · 2021Article
- Optical Brain Biopsy with a Fluorescence and Vessel Tracing Probe.Operative neurosurgery (Hagerstown, Md.) · 2021Article
- Combined autofluorescence and diffuse reflectance for brain tumour surgical guidance: initialBiomedical optics express · 2021Article
- Multispectral diffuse reflectance can discriminate blood vessels and bleeding during neurosurgery based on low-frequency hemodynamics.Journal of biomedical optics · 2020Article
- Rise of Raman spectroscopy in neurosurgery: a review.Journal of biomedical optics · 2020Review
- Spectral complexity of 5-ALA induced PpIX fluorescence in guided surgery: a clinical study towards the discrimination of healthy tissue and margin boundaries in high and low grade gliomas.Biomedical optics express · 2019Article
- Current Trends for Improving Safety of Stereotactic Brain Biopsies: Advanced Optical Methods for Vessel Avoidance and Tumor Detection.Frontiers in oncology · 2019Review
- Dual-modality optical diagnosis for preciseTheranostics · 2019Article
- Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans.Science advances · 2018Article
- In situ optical feedback in brain tumor biopsy: A multiparametric analysis.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A fiber optic probe was developed for guidance during stereotactic brain biopsy procedures to target tumor tissue and reduce the risk of hemorrhage. The probe was connected to a setup for the measurement of 5-aminolevulinic acid (5-ALA) induced fluorescence and microvascular blood flow. Along three stereotactic trajectories, fluorescence (n = 109) and laser Doppler flowmetry (LDF) (n = 144) measurements were done in millimeter increments. The recorded signals were compared to histopathology and radiology images. The median ratio of protoporphyrin IX (PpIX) fluorescence and autofluorescence (AF) in the tumor was considerably higher than the marginal zone (17.3 vs 0.9). The blood flow showed two high spots (3%) in total. The proposed setup allows simultaneous and real-time detection of tumor tissue and microvascular blood flow for tracking the vessels.
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