ArticleBiomedical optics express2018
Biodynamic digital holography of chemoresistance in a pre-clinical trial of canine B-cell lymphoma.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04891952 (Measuring the Impact of Onco4D® Guidance), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Measuring the Impact of Onco4D® Guidance
Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Comparative oncology chemosensitivity assay for personalized medicine using low-coherence digital holography of dynamic light scattering from cancer biopsies.Scientific reports · 2024Article
- Evaluating the feasibility and predictive accuracy of biodynamic imaging to platinum-based chemotherapy response in esophageal adenocarcinoma.Frontiers in oncology · 2024Article
- Imaging and characterization of transitions in biofilm morphology via anomalous diffusion following environmental perturbation.Biomedical optics express · 2022Article
- Tumor staging in a Beagle dog with concomitant large B-cell lymphoma and T-cell acute lymphoblastic leukemia.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
- Biodynamic signatures from ex vivo bone marrow aspirates are associated with chemotherapy-induced neutropenia in cancer-bearing dogs.Veterinary medicine and science · 2021Article
- Common-path interferometer for digital holographic Doppler spectroscopy of living biological tissues.Journal of biomedical optics · 2021Article
- Doppler imaging detects bacterial infection of living tissue.Communications biology · 2021Article
- Biodynamic digital holographic speckle microscopy for oocyte and embryo metabolic evaluation.Applied optics · 2021Article
- Intracellular optical doppler phenotypes of chemosensitivity in human epithelial ovarian cancer.Scientific reports · 2020Article
- RNA disruption indicates CHOP therapy efficacy in canine lymphoma.BMC veterinary research · 2019Article
- Intracellular Doppler Spectroscopy detects altered drug response in SKOV3 tumor spheroids with silenced or inhibited P-glycoprotein.Biochemical and biophysical research communications · 2019Article
- An optical study of drug resistance detection in endometrial cancer cells by dynamic and quantitative phase imaging.Journal of biophotonics · 2019Article
- Biodynamic optical assay for embryo viability.Journal of biomedical optics · 2019Article
- Doppler fluctuation spectroscopy of intracellular dynamics in living tissue.Journal of the Optical Society of America. A, Optics, image science, and vision · 2019Article
- Morphological changes in the ovarian carcinoma cells of Wistar rats induced by chemotherapy with cisplatin and dioxadet.Biomedical optics express · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Biodynamic digital holography was used to obtain phenotypic profiles of canine non-Hodgkin B-cell lymphoma biopsies treated with standard-of-care chemotherapy. Biodynamic signatures from the living 3D tissues were extracted using fluctuation spectroscopy from intracellular Doppler light scattering in response to the molecular mechanisms of action of therapeutic drugs that modify a range of internal cellular motions. The standard-of-care to treat B-cell lymphoma in both humans and dogs is a combination CHOP therapy that consists of doxorubicin, prednisolone, cyclophosphamide and vincristine. The proportion of dogs experiencing durable cancer remission following CHOP chemotherapy was 68%, with 13 out of 19 dogs responding favorably to therapy and 6 dogs failing to have progression-free survival times greater than 100 days. Biodynamic signatures were found that correlate with inferior survival times, and biomarker selection was optimized to identify specific Doppler signatures related to chemoresistance. A machine learning classifier was constructed based on feature vector correlations and linear separability in high-dimensional feature space. Hold-out validation predicted patient response to therapy with 84% accuracy. These results point to the potential for biodynamic profiling to contribute to personalized medicine by aiding the selection of chemotherapy for cancer patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.