ArticleBiomedical optics express2018
Fast volume-scanning light sheet microscopy reveals transient neuronal events.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Fast 3D dynamic visualization of porcine spermatozoa by using high-resolution wavefront coding light sheet microscopy and machine learning.Scientific reports · 2026Article
- Quantifying DNA damage following light sheet and confocal imaging of the mammalian embryo.Scientific reports · 2024Article
- Photonic neural probe enabled microendoscopes for light-sheet light-field computational fluorescence brain imaging.Neurophotonics · 2024Article
- Current and future applications of light-sheet imaging for identifying molecular and developmental processes in autism spectrum disorders.Molecular psychiatry · 2024Review
- Volumetric light sheet imaging with adaptive optics correction.Biomedical optics express · 2023Article
- Single-Lens Light-Sheet Fluorescence Microscopy Based on Micro-Mirror Array.Laser & photonics reviews · 2022Article
- Depth random-access two-photon Bessel light-sheet imaging in brain tissue.Optics express · 2022Article
- From whole organism to ultrastructure: progress in axonal imaging for decoding circuit development.Development (Cambridge, England) · 2021Review
- Real-time multi-angle projection imaging of biological dynamics.Nature methods · 2021Article
- Implantable photonic neural probes for light-sheet fluorescence brain imaging.Neurophotonics · 2021Article
- Light Sheet Illumination for 3D Single-Molecule Super-Resolution Imaging of Neuronal Synapses.Frontiers in synaptic neuroscience · 2021Review
- Integrated Neurophotonics: Toward Dense Volumetric Interrogation of Brain Circuit Activity-at Depth and in Real Time.Neuron · 2020Review
- Review
- VIEW-MOD: a versatile illumination engine with a modular optical design for fluorescence microscopy.Optics express · 2019Article
- Dispersion compensation by a liquid lens (DisCoBALL).Applied optics · 2019Article
- Applications of Light-Sheet Microscopy in Microdevices.Frontiers in neuroanatomy · 2019Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Light sheet fluorescence microscopy offers considerable potential to the cellular neuroscience community as it makes it possible to image extensive areas of neuronal structures, such as axons or dendrites, with a low light budget, thereby minimizing phototoxicity. However, the shallow depth of a light sheet, which is critical for achieving high contrast, well resolved images, adds a significant challenge if fast functional imaging is also required, as multiple images need to be collected across several image planes. Consequently, fast functional imaging of neurons is typically restricted to a small tissue volume where part of the neuronal structure lies within the plane of a single image. Here we describe a method by which fast functional imaging can be achieved across a much larger tissue volume; a custom-built light sheet microscope is presented that includes a synchronized galvo mirror and electrically tunable lens, enabling high speed acquisition of images across a configurable depth. We assess the utility of this technique by acquiring fast functional Ca
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