Evidence map›Paper›PMID 29760777›Full record

ArticleBiotechnology for biofuels2018

A

Georg Basler, Mitchell Thompson, Danielle Tullman-Ercek, Jay Keasling

Abstract read
In one paragraph

Article in Biotechnology for biofuels, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Microbial production of advanced biofuels.Nature reviews. Microbiology · 2021
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Diversifying Isoprenoid PlatformsFrontiers in microbiology · 2021
    Review
  17. Article
  18. Adaptive laboratory evolution ofMetabolic engineering communications · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Georg Basler1Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA USA.
Mitchell Thompson3Department of Plant & Microbial Biology, University of California, Berkeley, CA USA.
Danielle Tullman-Ercek5Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL USA.
Jay Keasling1Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe microbial production of biofuels is complicated by a tradeoff between yield and toxicity of many fuels. Efflux pumps enable bacteria to tolerate toxic substances by their removal from the cells while bypassing the periplasm. Their use for the microbial production of biofuels can help to improve cell survival, product recovery, and productivity. However, no native efflux pump is known to act on the class of short-chain alcohols, important next-generation biofuels, and it was considered unlikely that such an efflux pump exists.

resultsWe report that controlled expression of the RND-type efflux pump TtgABC from

conclusionsTtgABC is the first native efflux pump shown to act on multiple short-chain alcohols. Its controlled expression can be used to improve cell survival and increase production of biofuels as an orthogonal approach to metabolic engineering. Together with the increased interest in

Indexed as

Efflux pumpsHigher alcoholsNext-generation biofuelsPseudomonas putidaShort-chain alcoholsToleranceToxicityTtgABC

Identifiers

PMID29760777
PMCPMC5946390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.