Evidence map›Paper›PMID 29760719›Full record

ArticleStem cells international2018

IFN

Jun Zhou, Tian Liang, Dejun Wang, Liru Li, Yan Cheng, Qiuyan Guo, Guangmei Zhang

Open access · goldAbstract read
In one paragraph

Article in Stem cells international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jun ZhouThe First Affiliated Hospital of Harbin Medical University, Harbin, China.
Tian LiangThe First Affiliated Hospital of Harbin Medical University, Harbin, China.
Dejun WangThe First Affiliated Hospital of Harbin Medical University, Harbin, China.
Liru LiThe Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Yan ChengThe First Affiliated Hospital of Harbin Medical University, Harbin, China.
Qiuyan GuoThe First Affiliated Hospital of Harbin Medical University, Harbin, China.
Guangmei ZhangThe First Affiliated Hospital of Harbin Medical University, Harbin, China.ORCID 0000-0003-0211-5111
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmunotherapy for cervical cancer with type I interferon (IFN) is limited because of the cytotoxicity that accompanies the high doses that are administered. In this study, we investigated the utilization of amniotic fluid-derived mesenchymal stem cells (AF-MSCs) as a means for delivering IFN

methodsThe tumor tropism ability of AF-MSCs and AF-MSCs genetically modified to overexpress IFN

resultsIn this model, intravenously injected AF-MSCs selectively migrated to the tumor sites, participated in tumor construction, and promoted tumor growth. After being genetically modified to overexpress IFN

conclusionsIFN

Identifiers

PMID29760719
PMCPMC5901954
OpenAlexW2795720338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.