Evidence map›Paper›PMID 29760712›Full record

ReviewFrontiers in immunology2018

The Function of MicroRNAs in B-Cell Development, Lymphoma, and Their Potential in Clinical Practice.

Bing Zheng, Zhijiang Xi, Rong Liu, Wei Yin, Zhiwei Sui, Boxu Ren, Heather Miller, Quan Gong, Chaohong Liu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Bing ZhengDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Zhijiang XiDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Rong LiuDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Wei YinWuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhiwei SuiDivision of Medical and Biological Measurement, National Institute of Metrology, Beijing, China.
Boxu RenDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Heather MillerDepartment of Intracellular Pathogens, National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States.
Quan GongDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Chaohong LiuDepartment of Microbiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yangtze University · CNHuazhong University of Science and Technology · CNNational Institute of Allergy and Infectious Diseases · USNational Institute of Metrology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B-cell formation, development, and differentiation are complex processes regulated by several mechanisms. Recently, there has been growing evidence indicating that microRNAs (miRNAs) are important for normal B-cell lineage development. miRNAs are small non-coding RNA molecules, about 20-22 nucleotide in length, that play an important role in regulating gene expression. They pair with specific messenger RNAs (mRNAs), resulting in mRNAs translational repression or degradation. Here, we review current research about the function of miRNAs in the aspects of B-cell physiology and pathology. We start by introducing the process of miRNA biogenesis. We will then focus on the role of miRNAs during B-cell lineage commitment and development in the bone marrow, followed by a discussion of miRNAs' role in subsequent peripheral B-cell activation, proliferation, and final differentiation (including B-cell central tolerance and autoimmunity). We list and describe several examples to illustrate miRNAs' role in the development of B-cell lymphoma, both as oncogenes and tumor suppressor genes. Finally, we delineate the potential value of miRNAs in diagnosing B-cell lymphoma, predicting clinical outcomes, and modulating the efficiency of anticancer treatments. Despite the vast amount of research conducted on miRNAs in recent years, it is still necessary to increase and further strengthen studies on miRNAs and their targets to promote a better understanding on B-cell development and as a result, construct more effective treatments against B-cell disease.

Indexed as

Disease SusceptibilityAnimalsAutoimmunityBiomarkers, TumorB-LymphocytesBone Marrow CellsCell DifferentiationHumansImmune ToleranceLymphomaMicroRNAsMolecular Diagnostic TechniquesMolecular Targeted TherapyPrognosisBiomarkers, TumorMicroRNAsB cellbone marrowdiffuse large B-cell lymphomagerminal centerlymphomamicroRNAperipheral

Identifiers

PMID29760712
PMCPMC5936759
OpenAlexW2802141201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.