Evidence map›Paper›PMID 29760684›Full record

ArticleFrontiers in microbiology2018

Bioprospecting Deep-Sea Actinobacteria for Novel Anti-infective Natural Products.

Dongbo Xu, Linna Han, Chunhui Li, Qi Cao, Duolong Zhu, Nolan H Barrett, Dedra Harmody, Jing Chen, Haining Zhu, Peter J McCarthy and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Genus-specific secondary metabolome inSynthetic and systems biotechnology · 2024
    Article
  7. Animal Microbiomes as a Source of Novel Antibiotic-Producing Strains.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. The Extremophilic Actinobacteria: From Microbes to Medicine.Antibiotics (Basel, Switzerland) · 2021
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Antimicrobial resistance in nephrology.Nature reviews. Nephrology · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Dongbo XuHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL, United States.
Linna HanHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL, United States.
Chunhui LiDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Qi CaoHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL, United States.
Duolong ZhuDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Nolan H BarrettHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL, United States.
Dedra HarmodyHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL, United States.
Jing ChenDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, United States.
Haining ZhuDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, United States.
Peter J McCarthyHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL, United States.
Xingmin SunDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Guojun WangHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL, United States.
Florida Atlantic University · USUniversity of South Florida · USHarbor Branch Oceanographic Institute · USUniversity of Kentucky · US

Funding

Multivalent vaccines against Clostridium difficile infectionR01AI132711 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI Xingmin Sun, Shifeng Wang · 2017 to 2026
$3.3M
Signaling pathway of TNF-alpha production and Clostridium difficile infection (CDK01DK092352 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI SUN, XINGMIN · 2012 to 2016
$470k
Multivalent Bacillus mucosal vaccines against Clostridium difficile infectionR21AI113470 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SUN, XINGMIN · 2015 to 2016
$438k
Identifying the biosynthesis of a potent cytotoxic agent Lasonolide AR21CA209189 · NCI · FLORIDA ATLANTIC UNIVERSITY · PI WANG, GUOJUN · 2016 to 2017
$384k
The role of tumor progression locus 2 (TPL2) in the pathogenesis of Clostridium difficile infection (CDI)R03DK112004 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI SUN, XINGMIN · 2017 to 2018
$154k
NCI NIH HHS R21 CA209189NIAID NIH HHS R01 AI132711NIAID NIH HHS R21 AI113470NIDDK NIH HHS K01 DK092352NIDDK NIH HHS R03 DK112004
6 · The paper itself

Abstract

The global prevalence of drug resistance has created an urgent need for the discovery of novel anti-infective drugs. The major source of antibiotics in current clinical practice is terrestrial actinobacteria; the less-exploited deep-sea actinobacteria may serve as an unprecedented source of novel natural products. In this study, we evaluated 50 actinobacteria strains derived from diverse deep water sponges and environmental niches for their anti-microbial activities against a panel of pathogens including

Indexed as

actinobacteriaantibacterialantifungalanti-infectivedeep-sea spongedrug resistancelanthanum chloridenatural products

Identifiers

PMID29760684
PMCPMC5936781
OpenAlexW2802274358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.