Evidence map›Paper›PMID 29760648›Full record

ArticleFrontiers in molecular neuroscience2018

Profile of Arachidonic Acid-Derived Inflammatory Markers and Its Modulation by Nitro-Oleic Acid in an Inherited Model of Amyotrophic Lateral Sclerosis.

Andrés Trostchansky, Mauricio Mastrogiovanni, Ernesto Miquel, Sebastián Rodríguez-Bottero, Laura Martínez-Palma, Patricia Cassina, Homero Rubbo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andrés TrostchanskyDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Mauricio MastrogiovanniDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Ernesto MiquelCenter for Free Radical and Biomedical Research, Universidad de la República, Montevideo, Uruguay.
Sebastián Rodríguez-BotteroCenter for Free Radical and Biomedical Research, Universidad de la República, Montevideo, Uruguay.
Laura Martínez-PalmaCenter for Free Radical and Biomedical Research, Universidad de la República, Montevideo, Uruguay.
Patricia CassinaCenter for Free Radical and Biomedical Research, Universidad de la República, Montevideo, Uruguay.
Homero RubboDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Universidad de la República · UY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lack of current treatments for amyotrophic lateral sclerosis (ALS) highlights the need of a comprehensive understanding of the biological mechanisms of the disease. A consistent neuropathological feature of ALS is the extensive inflammation around motor neurons and axonal degeneration, evidenced by accumulation of reactive astrocytes and activated microglia. Final products of inflammatory processes may be detected as a screening tool to identify treatment response. Herein, we focus on (a) detection of arachidonic acid (AA) metabolization products by lipoxygenase (LOX) and prostaglandin endoperoxide H synthase in SOD1

Indexed as

ALSastrocytesinflammationlipidomicsmass spectrometryneurodegenerationnitro-fatty acid

Identifiers

PMID29760648
PMCPMC5936757
OpenAlexW2801717220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.