ArticleNature neuroscience2018
Two distinct mechanisms for experience-dependent homeostasis.
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Cortical functional connectivity in mouse models of early blindness: enucleation vs. anophthalmia.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Homeostatic scaling ensures behavioural stability during corticosterone negative feedback.Molecular psychiatry · 2026Article
- Reactivated thalamocortical plasticity alters neural activity in sensory-motor cortex during post-critical period.Progress in neurobiology · 2025Article
- The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice.Investigative ophthalmology & visual science · 2025Article
- Blockade of GluN2B-Containing NMDA Receptors Prevents Potentiation and Depression of Responses during Ocular Dominance Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Multiomics of early epileptogenesis in mice reveals phosphorylation and dephosphorylation-directed growth and synaptic weakening.iScience · 2024Article
- Amyloid Pathology Impairs Experience-Dependent Inhibitory Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Loss of Depalmitoylation Disrupts Homeostatic Plasticity of AMPARs in a Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments.Proceedings of the National Academy of Sciences of the United States of America · 2023Review
- Age-related dysregulation of homeostatic control in neuronal microcircuits.Nature neuroscience · 2023Article
- Amyloid pathology impairs experience-dependent inhibitory synaptic plasticity.bioRxiv : the preprint server for biology · 2023Article
- Crossmodal plasticity in hearing loss.Trends in neurosciences · 2023Review
- Thalamic regulation of a visual critical period and motor behavior.Cell reports · 2023Article
- Excitation-inhibition imbalance disrupts visual familiarity in amyloid and non-pathology conditions.Cell reports · 2023Article
- Homeostatic regulation through strengthening of neuronal network-correlated synaptic inputs.eLife · 2022Article
- Article
- Differentiation of Hebbian and homeostatic plasticity mechanisms within layer 5 visual cortex neurons.Cell reports · 2022Article
- Metaplasticity framework for cross-modal synaptic plasticity in adults.Frontiers in synaptic neuroscience · 2022Review
- Memory destabilization during reconsolidation: a consequence of homeostatic plasticity?Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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Abstract
Models of firing rate homeostasis such as synaptic scaling and the sliding synaptic plasticity modification threshold predict that decreasing neuronal activity (for example, by sensory deprivation) will enhance synaptic function. Manipulations of cortical activity during two forms of visual deprivation, dark exposure (DE) and binocular lid suture, revealed that, contrary to expectations, spontaneous firing in conjunction with loss of visual input is necessary to lower the threshold for Hebbian plasticity and increase miniature excitatory postsynaptic current (mEPSC) amplitude. Blocking activation of GluN2B receptors, which are upregulated by DE, also prevented the increase in mEPSC amplitude, suggesting that DE potentiates mEPSCs primarily through a Hebbian mechanism, not through synaptic scaling. Nevertheless, NMDA-receptor-independent changes in mEPSC amplitude consistent with synaptic scaling could be induced by extreme reductions of activity. Therefore, two distinct mechanisms operate within different ranges of neuronal activity to homeostatically regulate synaptic strength.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.