Evidence map›Paper›PMID 29760502›Full record

ReviewNature reviews. Gastroenterology & hepatology2018

Infant colic: mechanisms and management.

Judith Zeevenhooven, Pamela D Browne, Monique P L'Hoir, Carolina de Weerth, Marc A Benninga

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 81 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03939611 nacompletednot on this map

The Effect of Foot Reflexology on Infantile Colic Symptoms: Randomized, Placebo-Controlled Trial

TypeinterventionalSponsorAkdeniz UniversityRan2016 to 2017Enrolled45ConditionsInfantile Colic, ReflexologyArmsFoot Reflexology, Placebo Foot Reflexology
NCT06197100 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effectiveness of Supportive Care Training Given to Mothers of Babies With Infant Colic: Randomized Controlled Study

TypeinterventionalSponsorKirsehir Ahi Evran UniversitesiRan2024 to 2024Enrolled60ConditionsMothers, Infantile ColicArmsSupportive care training, control grups
NCT06299358 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Effect of Foot Massage and Maternal Heart Sound on Colic and Comfort Levels in Infants With Infantile Colic

TypeinterventionalSponsorKaramanoğlu Mehmetbey UniversityRan2023 to 2025Enrolled90ConditionsNurse's Role, Infantile ColicArmsFoot massage, Mother heart sound, Foot massage and maternal heart sound
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  19. The Gut in Early Life-Postnatal Challenges.Children (Basel, Switzerland) · 2026
    Review
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Judith ZeevenhoovenDepartment of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital/Academic Medical Center, Amsterdam, Netherlands. j.zeevenhooven@amc.uva.nl.
Pamela D BrowneDepartment of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital/Academic Medical Center, Amsterdam, Netherlands.
Monique P L'HoirNutrition and Health over the Lifecourse, Wageningen University & Research, Wageningen, Netherlands.
Carolina de WeerthDevelopmental Psychology, Behavioral Science Institute, Radboud University, Nijmegen, Netherlands.
Marc A BenningaDepartment of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital/Academic Medical Center, Amsterdam, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infant colic is a commonly reported phenomenon of excessive crying in infancy with an enigmatic and distressing character. Despite its frequent occurrence, little agreement has been reached on the definition, pathogenesis or the optimal management strategy for infant colic. This Review aims to delineate the definitional entanglement with the Rome IV criteria, which were published in 2016, as the leading, most recent diagnostic criteria. Moreover, neurogenic, gastrointestinal, microbial and psychosocial factors that might contribute to the pathophysiology of infant colic are explored. This Review underlines that a comprehensive medical history and physical examination in the absence of alarm symptoms serve as guidance for the clinician to a positive diagnosis. It also highlights that an important aspect of the management of infant colic is parental education and reassurance. Management strategies, including behavioural, dietary, pharmacological and alternative interventions, are also discussed. Owing to a lack of large, high-quality randomized controlled trials, none of these therapies are strongly recommended. Finally, the behavioural and somatic sequelae of infant colic into childhood are summarized.

Indexed as

Bile Acids and SaltsBreast FeedingChild, PreschoolClothingColicComplementary TherapiesCryingDevelopmental DisabilitiesDiagnosis, DifferentialFather-Child RelationsFemaleGastrointestinal MicrobiomeHumansInfantInfant FormulaInfant, NewbornBile Acids and Salts

Identifiers

PMID29760502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.