Evidence map›Paper›PMID 29760465›Full record

ArticleNature communications2018

Neural encoding and production of functional morphemes in the posterior temporal lobe.

Daniel K Lee, Evelina Fedorenko, Mirela V Simon, William T Curry, Brian V Nahed, Dan P Cahill, Ziv M Williams

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. A Shared Neural Mechanism for Abstract Grammatical Computations across Languages in Bilinguals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  5. Article
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  8. Spatiotemporally distributed frontotemporal networks for sentence reading.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Minimal Phrase Composition Revealed by Intracranial Recordings.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  10. Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel K LeeDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, MA, USA.
Evelina FedorenkoDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, MA, USA.ORCID http://orcid.org/0000-0003-3823-514X
Mirela V SimonDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, MA, USA.
William T CurryDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, MA, USA.
Brian V NahedDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, MA, USA.
Dan P CahillDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, MA, USA.
Ziv M WilliamsDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, MA, USA. zwilliams@mgh.harvard.edu.

Funding

Neuronal based prosthetic control of volitional movementR01HD059852 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI WILLIAMS, ZIV · 2009 to 2015
$2.0M
Studying Memory Retrieval at the Dynamic Neural Network LevelR01NS091390 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WILLIAMS, ZIV · 2015 to 2019
$1.8M
NIH HHS R01HD059852NIH HHS R01NS091390
6 · The paper itself

Abstract

Morphemes are the smallest meaning-carrying units in human language, and are among the most basic building blocks through which humans express specific ideas and concepts. By using time-resolved cortical stimulations, neural recordings, and focal lesion evaluations, we show that inhibition of a small cortical area within the left dominant posterior-superior temporal lobe selectively impairs the ability to produce appropriate functional morphemes but does not distinctly affect semantic and lexical retrieval, comprehension, or articulation. Additionally, neural recordings within this area reveal the localized encoding of morphological properties and their planned production prior to speech onset. Finally, small lesions localized to the gray matter in this area result in a selective functional morpheme-production deficit. Collectively, these findings reveal a detailed division of linguistic labor within the posterior-superior temporal lobe and suggest that functional morpheme processing constitutes an operationally discrete step in the series of computations essential to language production.

Indexed as

LanguageAdultAstrocytomaBrain MappingBrain NeoplasmsComprehensionCraniotomyElectric StimulationFemaleGlioblastomaGray MatterHumansMagnetic Resonance ImagingMalePhoneticsSemantics

Identifiers

PMID29760465
PMCPMC5951905

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.