ArticleNature communications2018
Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 49 citations in OpenAlex.
- Experience and behavior modulate piriform cortex odor representation in freely moving mice.iScience · 2026Article
- Prominent involvement of acetylcholine dynamics in stable olfactory representation across the Drosophila brain.Nature communications · 2025Article
- Dopaminergic short axon cells integrate sensory and top-down inputs to enhance discriminative learning in the mouse olfactory bulb.PLoS biology · 2025Article
- Basal forebrain cholinergic input mediates adaptive attention allocation to enhance olfactory discrimination.PLoS biology · 2025Article
- Manifold learning for olfactory habituation to strongly fluctuating backgrounds.bioRxiv : the preprint server for biology · 2025Article
- Cerebral Blood Flow Responses to Trigeminal Olfactory Stimulation and Their Nicotinic Cholinergic Regulation in Anesthetized Rats.The European journal of neuroscience · 2025Article
- Distinct Patterns of PV and SST GABAergic Neuronal Activity in the Basal Forebrain during Olfactory-Guided Behavior in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Recent odor experience selectively modulates olfactory sensitivity across the glomerular output in the mouse olfactory bulb.Chemical senses · 2025Article
- Recent odor experience selectively modulates olfactory sensitivity across the glomerular output in the mouse olfactory bulb.bioRxiv : the preprint server for biology · 2024Article
- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- Imaging different cell populations in the mouse olfactory bulb using the genetically encoded voltage indicator ArcLight.Neurophotonics · 2024Review
- SARS-CoV-2-Related Olfactory Dysfunction: Autopsy Findings, Histopathology, and Evaluation of Viral RNA and ACE2 Expression in Olfactory Bulbs.Biomedicines · 2024Article
- Organizational Principles of the Centrifugal Projections to the Olfactory Bulb.International journal of molecular sciences · 2023Article
- Organization and engagement of a prefrontal-olfactory network during olfactory selective attention.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- AThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- The Response Dynamics and Function of Cholinergic and GABAergic Neurons in the Basal Forebrain During Olfactory Learning.Frontiers in cellular neuroscience · 2022Article
- Dynamic Cholinergic Tone in the Basal Forebrain Reflects Reward-Seeking and Reinforcement During Olfactory Behavior.Frontiers in cellular neuroscience · 2021Article
- Stimulus Driven Functional Transformations in the Early Olfactory System.Frontiers in cellular neuroscience · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Habituation and dishabituation modulate the neural resources and behavioral significance allocated to incoming stimuli across the sensory systems. We characterize these processes in the mouse olfactory bulb (OB) and uncover a role for OB acetylcholine (ACh) in physiological and behavioral olfactory dishabituation. We use calcium imaging in both awake and anesthetized mice to determine the time course and magnitude of OB glomerular habituation during a prolonged odor presentation. In addition, we develop a novel behavioral investigation paradigm to determine how prolonged odor input affects odor salience. We find that manipulating OB ACh release during prolonged odor presentations using electrical or optogenetic stimulation rapidly modulates habituated glomerular odor responses and odor salience, causing mice to suddenly investigate a previously ignored odor. To demonstrate the ethological validity of this effect, we show that changing the visual context can lead to dishabituation of odor investigation behavior, which is blocked by cholinergic antagonists in the OB.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.